Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

The most advanced P. falciparum circumsporozoite protein (PfCSP)-based malaria vaccine confers partial protection. Here, Pholcharee et al. present crystal structures, binding affinities/kinetics, and in vivo protection of 8 anti-NANP antibodies to understand in vivo protection of PfCSP-targeting ant...

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Autores principales:	Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Gonzalo Gonzalez-Paez, Zhen Han, Katherine L. Williams, Wayne Volkmuth, Daniel Emerling, Emily Locke, C. Richter King, Fidel Zavala, Ian A. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f69e762087b34c9ba0a1c8a3d1c005e9
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spelling	oai:doaj.org-article:f69e762087b34c9ba0a1c8a3d1c005e92021-12-02T14:21:20ZStructural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum10.1038/s41467-021-21221-42041-1723https://doaj.org/article/f69e762087b34c9ba0a1c8a3d1c005e92021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21221-4https://doaj.org/toc/2041-1723The most advanced P. falciparum circumsporozoite protein (PfCSP)-based malaria vaccine confers partial protection. Here, Pholcharee et al. present crystal structures, binding affinities/kinetics, and in vivo protection of 8 anti-NANP antibodies to understand in vivo protection of PfCSP-targeting antibodies.Tossapol PholchareeDavid OyenYevel Flores-GarciaGonzalo Gonzalez-PaezZhen HanKatherine L. WilliamsWayne VolkmuthDaniel EmerlingEmily LockeC. Richter KingFidel ZavalaIan A. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tossapol Pholcharee David Oyen Yevel Flores-Garcia Gonzalo Gonzalez-Paez Zhen Han Katherine L. Williams Wayne Volkmuth Daniel Emerling Emily Locke C. Richter King Fidel Zavala Ian A. Wilson Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
description	The most advanced P. falciparum circumsporozoite protein (PfCSP)-based malaria vaccine confers partial protection. Here, Pholcharee et al. present crystal structures, binding affinities/kinetics, and in vivo protection of 8 anti-NANP antibodies to understand in vivo protection of PfCSP-targeting antibodies.
format	article
author	Tossapol Pholcharee David Oyen Yevel Flores-Garcia Gonzalo Gonzalez-Paez Zhen Han Katherine L. Williams Wayne Volkmuth Daniel Emerling Emily Locke C. Richter King Fidel Zavala Ian A. Wilson
author_facet	Tossapol Pholcharee David Oyen Yevel Flores-Garcia Gonzalo Gonzalez-Paez Zhen Han Katherine L. Williams Wayne Volkmuth Daniel Emerling Emily Locke C. Richter King Fidel Zavala Ian A. Wilson
author_sort	Tossapol Pholcharee
title	Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
title_short	Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
title_full	Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
title_fullStr	Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
title_full_unstemmed	Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
title_sort	structural and biophysical correlation of anti-nanp antibodies with in vivo protection against p. falciparum
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f69e762087b34c9ba0a1c8a3d1c005e9
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Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

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