lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p

Ovarian cancer is a kind of cancer from the female genital tract; the molecular mechanism still needs to be explored. lncRNA plays a vital role in tumorigenesis and development. Our aim was to identify oncogenic lncRNAs in ovarian cancer and explore the potential molecular mechanism. SNHG15 was init...

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Autores principales:	Yi Wang, Minghong Ding, Xiaoqing Yuan, Ruibao Jiao, Dagao Zhu, Wanzhong Huang, Wenxia Deng, Yulong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/f69ec05e8fdb4c608b8dc5dbb8b4430b
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spelling	oai:doaj.org-article:f69ec05e8fdb4c608b8dc5dbb8b4430b2021-11-08T02:36:34ZlncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p2314-614110.1155/2021/9394563https://doaj.org/article/f69ec05e8fdb4c608b8dc5dbb8b4430b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9394563https://doaj.org/toc/2314-6141Ovarian cancer is a kind of cancer from the female genital tract; the molecular mechanism still needs to be explored. lncRNA plays a vital role in tumorigenesis and development. Our aim was to identify oncogenic lncRNAs in ovarian cancer and explore the potential molecular mechanism. SNHG15 was initially identified by using GEO datasets (GSE135886 and GSE119054) and validated by tumor tissues and the cell line, identifying that SNHG15 was upregulated in ovarian cancer. Besides, high SNHG15 indicated poor prognosis in ovarian cancer. Furthermore, knockdown SNHG15 suppresses ovarian cancer proliferation and promotes apoptosis. Mechanistically, SNHG15 promotes proliferation through upregulated CDK6 via sponging miR-370-3p. Taken together, our findings emphasize the important role of SNHG15 in ovarian cancer, suggesting that SNHG15 may be a promising target for ovarian cancer.Yi WangMinghong DingXiaoqing YuanRuibao JiaoDagao ZhuWanzhong HuangWenxia DengYulong LiuHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Yi Wang Minghong Ding Xiaoqing Yuan Ruibao Jiao Dagao Zhu Wanzhong Huang Wenxia Deng Yulong Liu lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
description	Ovarian cancer is a kind of cancer from the female genital tract; the molecular mechanism still needs to be explored. lncRNA plays a vital role in tumorigenesis and development. Our aim was to identify oncogenic lncRNAs in ovarian cancer and explore the potential molecular mechanism. SNHG15 was initially identified by using GEO datasets (GSE135886 and GSE119054) and validated by tumor tissues and the cell line, identifying that SNHG15 was upregulated in ovarian cancer. Besides, high SNHG15 indicated poor prognosis in ovarian cancer. Furthermore, knockdown SNHG15 suppresses ovarian cancer proliferation and promotes apoptosis. Mechanistically, SNHG15 promotes proliferation through upregulated CDK6 via sponging miR-370-3p. Taken together, our findings emphasize the important role of SNHG15 in ovarian cancer, suggesting that SNHG15 may be a promising target for ovarian cancer.
format	article
author	Yi Wang Minghong Ding Xiaoqing Yuan Ruibao Jiao Dagao Zhu Wanzhong Huang Wenxia Deng Yulong Liu
author_facet	Yi Wang Minghong Ding Xiaoqing Yuan Ruibao Jiao Dagao Zhu Wanzhong Huang Wenxia Deng Yulong Liu
author_sort	Yi Wang
title	lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title_short	lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title_full	lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title_fullStr	lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title_full_unstemmed	lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p
title_sort	lncrna snhg15 promotes ovarian cancer progression through regulated cdk6 via sponging mir-370-3p
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/f69ec05e8fdb4c608b8dc5dbb8b4430b
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lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR-370-3p

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