Modeling the effects of EMT-immune dynamics on carcinoma disease progression
Bergman, Karikomi et al. propose a multiscale evolutionary model to describe tumor-immune-EMT interactions and their impact on epithelial cancer progression, which highlights a controllable region that maximizes invasion-free survival. Using EMT-inflammation associated TCGA data, the authors find EM...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/f69f8c00bcdf4bb0ab8fdb4757e03707 |
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| Sumario: | Bergman, Karikomi et al. propose a multiscale evolutionary model to describe tumor-immune-EMT interactions and their impact on epithelial cancer progression, which highlights a controllable region that maximizes invasion-free survival. Using EMT-inflammation associated TCGA data, the authors find EMT association worsens invasion-free survival and identify genes that influence outcomes in bladder and uterine cancer. |
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