Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.

Fast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic...

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Autores principales:	Nathan W Gouwens, Hugo Zeberg, Kunichika Tsumoto, Takashi Tateno, Kazuyuki Aihara, Hugh P C Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f6a1e49bc8b24eee87162c4efe1f3288
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spelling	oai:doaj.org-article:f6a1e49bc8b24eee87162c4efe1f32882021-11-18T05:50:55ZSynchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.1553-734X1553-735810.1371/journal.pcbi.1000951https://doaj.org/article/f6a1e49bc8b24eee87162c4efe1f32882010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941393/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Fast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic interactions control synchronization, artificial synaptic conductances were injected in FS cells, and the synaptic phase-resetting function (SPRF), describing how the compound synaptic input perturbs the phase of gamma-frequency spiking as a function of the phase at which it is applied, was measured. GABAergic and gap junctional conductances made distinct contributions to the SPRF, which had a surprisingly simple piecewise linear form, with a sharp midcycle break between phase delay and advance. Analysis of the SPRF showed how the intrinsic biophysical properties of FS neurons and their interconnections allow entrainment of firing over a wide gamma frequency band, whose upper and lower frequency limits are controlled by electrical synapses and GABAergic inhibition respectively.Nathan W GouwensHugo ZebergKunichika TsumotoTakashi TatenoKazuyuki AiharaHugh P C RobinsonPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 6, Iss 9 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nathan W Gouwens Hugo Zeberg Kunichika Tsumoto Takashi Tateno Kazuyuki Aihara Hugh P C Robinson Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.
description	Fast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic interactions control synchronization, artificial synaptic conductances were injected in FS cells, and the synaptic phase-resetting function (SPRF), describing how the compound synaptic input perturbs the phase of gamma-frequency spiking as a function of the phase at which it is applied, was measured. GABAergic and gap junctional conductances made distinct contributions to the SPRF, which had a surprisingly simple piecewise linear form, with a sharp midcycle break between phase delay and advance. Analysis of the SPRF showed how the intrinsic biophysical properties of FS neurons and their interconnections allow entrainment of firing over a wide gamma frequency band, whose upper and lower frequency limits are controlled by electrical synapses and GABAergic inhibition respectively.
format	article
author	Nathan W Gouwens Hugo Zeberg Kunichika Tsumoto Takashi Tateno Kazuyuki Aihara Hugh P C Robinson
author_facet	Nathan W Gouwens Hugo Zeberg Kunichika Tsumoto Takashi Tateno Kazuyuki Aihara Hugh P C Robinson
author_sort	Nathan W Gouwens
title	Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.
title_short	Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.
title_full	Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.
title_fullStr	Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.
title_full_unstemmed	Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.
title_sort	synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/f6a1e49bc8b24eee87162c4efe1f3288
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Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.

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