DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing
Unresolved R-loops can represent a threat to genome stability. Here the authors reveal that DHX9 helicase can promote R-loop formation in the absence of splicing factors SFPQ and SF3B3.
Enregistré dans:
Auteurs principaux: | Prasun Chakraborty, Jeffrey T. J. Huang, Kevin Hiom |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/f6a6b01d7c104d91b1ab6b903aaebe70 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination
par: Prasun Chakraborty, et autres
Publié: (2021) -
The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
par: Roberto Melero, et autres
Publié: (2016) -
R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
par: Chun-Ying Lee, et autres
Publié: (2020) -
PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes
par: Phong Lan Thao Tran, et autres
Publié: (2017) -
Helicase promotes replication re-initiation from an RNA transcript
par: Bo Sun, et autres
Publié: (2018)