Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets

The present study was conducted to evaluate the efficacy of the feed additive, a novel multicomponent mycotoxin detoxifying agent (MMDA) containing modified zeolite (clinoptilolite), Bacillus subtilis, B. licheniformis, Saccharomyces cerevisiae...

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Autores principales:	Insaf Riahi, Antonio J. Ramos, Jog Raj, Zdenka Jakovčević, Hunor Farkaš, Marko Vasiljević, Anna Maria Pérez-Vendrell
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ochratoxin A T-2 mycotoxin broiler chickens mycotoxin binder Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/f6a6fcba8bd742ee8d9e843289ac078a
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spelling	oai:doaj.org-article:f6a6fcba8bd742ee8d9e843289ac078a2021-11-25T16:19:02ZEffect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets10.3390/ani111132052076-2615https://doaj.org/article/f6a6fcba8bd742ee8d9e843289ac078a2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3205https://doaj.org/toc/2076-2615The present study was conducted to evaluate the efficacy of the feed additive, a novel multicomponent mycotoxin detoxifying agent (MMDA) containing modified zeolite (clinoptilolite), <i>Bacillus subtilis</i>, <i>B. licheniformis</i>, <i>Saccharomyces cerevisiae</i> cell walls, and silymarin, as detoxifiers of 0.5 mg/kg (0.5 ppm) ochratoxin A (OTA) and 1 mg/kg (1 ppm) T-2 toxin on broiler chickens. A total of 240 1-old broiler chickens (Ross 308) were randomly distributed into five different dietary treatments: (1) control (non-contaminated diet); (2) non contaminated diet + 3 g/kg of MMDA; (3) non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin; (4) non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin + 1 g/kg MMDA; and (5) non-contaminated diet + 0.5 mg/kg OTA + 1 g/kg T-2 toxin + 3 g/kg MMDA. The results showed that, in the starter period, from 1 to 10 days, the presence of OTA and T-2 mycotoxins reduced the consumption of feed and the growth of the broilers, and no effects of the detoxifying product were observed in the productivity of the chickens, at any of the doses tested, compared to the contaminated control (treatment 3). However, in the growing period, the same negative effect of mycotoxins was registered, but a recovery was observed in the consumption of feed and in the weight of the broilers that consumed 3 g/kg of the MMDA mycotoxin binder, reaching similar values to those of chickens fed uncontaminated control diets. The presence of mycotoxins in feed led to a reduction in the concentration of total proteins and albumin in blood compared to controls, and the presence of the detoxifying product partially reversed this effect. The breast yield of the chickens fed with mycotoxins was lower than that of the animals fed with the control feed and was not affected by the presence of the product tested, at 1 or 3 g/kg. The weight of the different organs (liver, gizzard, kidneys, or spleen), the intestinal pH, the histology of the small intestine, and oral lesions were not affected by the experimental treatments. In summary, the productive parameters and some blood and carcass characteristics of broiler chickens were impaired by the dietary presence of OTA and T-2 toxin. The tested product included at 1 or 3 g/kg feed in contaminated diets improved performance and seems to be effective in partly counteracting the deleterious effects of the tested mycotoxins.Insaf RiahiAntonio J. RamosJog RajZdenka JakovčevićHunor FarkašMarko VasiljevićAnna Maria Pérez-VendrellMDPI AGarticleochratoxin AT-2 mycotoxinbroiler chickensmycotoxin binderVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3205, p 3205 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ochratoxin A T-2 mycotoxin broiler chickens mycotoxin binder Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	ochratoxin A T-2 mycotoxin broiler chickens mycotoxin binder Veterinary medicine SF600-1100 Zoology QL1-991 Insaf Riahi Antonio J. Ramos Jog Raj Zdenka Jakovčević Hunor Farkaš Marko Vasiljević Anna Maria Pérez-Vendrell Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets
description	The present study was conducted to evaluate the efficacy of the feed additive, a novel multicomponent mycotoxin detoxifying agent (MMDA) containing modified zeolite (clinoptilolite), <i>Bacillus subtilis</i>, <i>B. licheniformis</i>, <i>Saccharomyces cerevisiae</i> cell walls, and silymarin, as detoxifiers of 0.5 mg/kg (0.5 ppm) ochratoxin A (OTA) and 1 mg/kg (1 ppm) T-2 toxin on broiler chickens. A total of 240 1-old broiler chickens (Ross 308) were randomly distributed into five different dietary treatments: (1) control (non-contaminated diet); (2) non contaminated diet + 3 g/kg of MMDA; (3) non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin; (4) non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin + 1 g/kg MMDA; and (5) non-contaminated diet + 0.5 mg/kg OTA + 1 g/kg T-2 toxin + 3 g/kg MMDA. The results showed that, in the starter period, from 1 to 10 days, the presence of OTA and T-2 mycotoxins reduced the consumption of feed and the growth of the broilers, and no effects of the detoxifying product were observed in the productivity of the chickens, at any of the doses tested, compared to the contaminated control (treatment 3). However, in the growing period, the same negative effect of mycotoxins was registered, but a recovery was observed in the consumption of feed and in the weight of the broilers that consumed 3 g/kg of the MMDA mycotoxin binder, reaching similar values to those of chickens fed uncontaminated control diets. The presence of mycotoxins in feed led to a reduction in the concentration of total proteins and albumin in blood compared to controls, and the presence of the detoxifying product partially reversed this effect. The breast yield of the chickens fed with mycotoxins was lower than that of the animals fed with the control feed and was not affected by the presence of the product tested, at 1 or 3 g/kg. The weight of the different organs (liver, gizzard, kidneys, or spleen), the intestinal pH, the histology of the small intestine, and oral lesions were not affected by the experimental treatments. In summary, the productive parameters and some blood and carcass characteristics of broiler chickens were impaired by the dietary presence of OTA and T-2 toxin. The tested product included at 1 or 3 g/kg feed in contaminated diets improved performance and seems to be effective in partly counteracting the deleterious effects of the tested mycotoxins.
format	article
author	Insaf Riahi Antonio J. Ramos Jog Raj Zdenka Jakovčević Hunor Farkaš Marko Vasiljević Anna Maria Pérez-Vendrell
author_facet	Insaf Riahi Antonio J. Ramos Jog Raj Zdenka Jakovčević Hunor Farkaš Marko Vasiljević Anna Maria Pérez-Vendrell
author_sort	Insaf Riahi
title	Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets
title_short	Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets
title_full	Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets
title_fullStr	Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets
title_full_unstemmed	Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets
title_sort	effect of a mycotoxin binder (mmda) on the growth performance, blood and carcass characteristics of broilers fed ochratoxin a and t-2 mycotoxin contaminated diets
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f6a6fcba8bd742ee8d9e843289ac078a
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Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets

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