Why Do Influenza Virus Subtypes Die Out? A Hypothesis

ABSTRACT Novel pandemic influenza viruses enter the human population with some regularity and can cause disease that is severe and widespread. The emergence of novel viruses, historically, has often been coupled with the disappearance of existing seasonal virus strains. Here, we propose that the eli...

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Autores principales:	Peter Palese, Taia T. Wang
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2011
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f6a879c812b04a77be0303a032292d34
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spelling	oai:doaj.org-article:f6a879c812b04a77be0303a032292d342021-11-15T15:38:58ZWhy Do Influenza Virus Subtypes Die Out? A Hypothesis10.1128/mBio.00150-112150-7511https://doaj.org/article/f6a879c812b04a77be0303a032292d342011-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00150-11https://doaj.org/toc/2150-7511ABSTRACT Novel pandemic influenza viruses enter the human population with some regularity and can cause disease that is severe and widespread. The emergence of novel viruses, historically, has often been coupled with the disappearance of existing seasonal virus strains. Here, we propose that the elimination of seasonal strains during virus pandemics is a process mediated, at the population level, by humoral immunity. Specifically, we suggest that infection with a novel virus strain, in people previously exposed to influenza viruses, can elicit a memory B cell response against conserved hemagglutinin stalk epitopes and/or neuraminidase epitopes. The anti-stalk and/or anti-neuraminidase antibodies then act to diminish the clinical severity of disease caused by novel influenza viruses and to eliminate seasonal virus strains.Peter PaleseTaia T. WangAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 2, Iss 5 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Peter Palese Taia T. Wang Why Do Influenza Virus Subtypes Die Out? A Hypothesis
description	ABSTRACT Novel pandemic influenza viruses enter the human population with some regularity and can cause disease that is severe and widespread. The emergence of novel viruses, historically, has often been coupled with the disappearance of existing seasonal virus strains. Here, we propose that the elimination of seasonal strains during virus pandemics is a process mediated, at the population level, by humoral immunity. Specifically, we suggest that infection with a novel virus strain, in people previously exposed to influenza viruses, can elicit a memory B cell response against conserved hemagglutinin stalk epitopes and/or neuraminidase epitopes. The anti-stalk and/or anti-neuraminidase antibodies then act to diminish the clinical severity of disease caused by novel influenza viruses and to eliminate seasonal virus strains.
format	article
author	Peter Palese Taia T. Wang
author_facet	Peter Palese Taia T. Wang
author_sort	Peter Palese
title	Why Do Influenza Virus Subtypes Die Out? A Hypothesis
title_short	Why Do Influenza Virus Subtypes Die Out? A Hypothesis
title_full	Why Do Influenza Virus Subtypes Die Out? A Hypothesis
title_fullStr	Why Do Influenza Virus Subtypes Die Out? A Hypothesis
title_full_unstemmed	Why Do Influenza Virus Subtypes Die Out? A Hypothesis
title_sort	why do influenza virus subtypes die out? a hypothesis
publisher	American Society for Microbiology
publishDate	2011
url	https://doaj.org/article/f6a879c812b04a77be0303a032292d34
work_keys_str_mv	AT peterpalese whydoinfluenzavirussubtypesdieoutahypothesis AT taiatwang whydoinfluenzavirussubtypesdieoutahypothesis
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Why Do Influenza Virus Subtypes Die Out? A Hypothesis

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