EFFICIENCY OF LICOPID IN THE PATIENTS WITH CHRONIC ABACTERIAL PROSTATITIS COMPLICATED WITH FERTILITY DISORDERS

Abstract. The study was aimed for evaluation of clinical and immunological efficiency of an immunomodulating drug Licopid (Peptec «CJSC») in chronic abacterial prostatitis (CAP) accompanied by fertility alterations. Licopid contains N-acetylglucoseaminil-β1-4-acetylmuramoyl-L-alanyl-D-isoglutamine (...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. V. Semyonov, N. Yu. Sotnikova, A. A. Martenova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	male infertility sperm morphology chronic abacterial prostatitis licopid mononuclear cells pathogen-associated molecular patterns Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f6a95183a128439195ebe2e02f3ea69f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f6a95183a128439195ebe2e02f3ea69f
record_format	dspace
spelling	oai:doaj.org-article:f6a95183a128439195ebe2e02f3ea69f2021-11-18T08:03:39ZEFFICIENCY OF LICOPID IN THE PATIENTS WITH CHRONIC ABACTERIAL PROSTATITIS COMPLICATED WITH FERTILITY DISORDERS1563-06252313-741X10.15789/1563-0625-2007-4-5-435-446https://doaj.org/article/f6a95183a128439195ebe2e02f3ea69f2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/201https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The study was aimed for evaluation of clinical and immunological efficiency of an immunomodulating drug Licopid (Peptec «CJSC») in chronic abacterial prostatitis (CAP) accompanied by fertility alterations. Licopid contains N-acetylglucoseaminil-β1-4-acetylmuramoyl-L-alanyl-D-isoglutamine (GMDP) which mimics a minimal repeated peptidoglycan structural unit from bacterial cell wall, and it represents a pathogen-associated molecular pattern, able to influence the innate immune system via appropriate pattern-recognition receptors. Thirty-eight infertile patients with azoospermia were under observation (20 to 45 years old, a mean of 28.84±1.1). CAP was diagnosed in accordance with NIH criteria, as chronic prostatitis of III-A category. Clinical examination included sperm analysis, using WHO criteria, and phenotyping of peripheral blood mononuclear cells, by the means of standard flow cytometry (FACScan, «Becton Dickinson»). A control group consisted of eight fertile males 21 to 33 years old (a mean of 26.8±2.33) with normozoospermia. For twenty-four randomly selected patients (main group), a treatment with Licopid was applied (a total of 100 mg, at a daily oral dose of 10 mg), in addition to common therapeutic schedule (fluorochinolones, α-adrenoblockers). A comparison group included fourteen patients receiving common therapy. Some differences in immune response were detectable in the CAP patients. Along with balanced («intense») state of immunity revealed in 16 subjects, 22 persons did exhibit a systemic immunosuppression which manifested as alterations in MNC activation and decreasing efficiency of the standard treatment. Licopid seems to be a drug of choice for these cases, due to decreased CAP activity and normalization of a spermogram following its application. Differentiated administration of immune modulating drugs will allow prevention of adverse effects of empirical immunocorrection.A. V. SemyonovN. Yu. SotnikovaA. A. MartenovaSPb RAACIarticlemale infertilitysperm morphologychronic abacterial prostatitislicopidmononuclear cellspathogen-associated molecular patternsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 435-446 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	male infertility sperm morphology chronic abacterial prostatitis licopid mononuclear cells pathogen-associated molecular patterns Immunologic diseases. Allergy RC581-607
spellingShingle	male infertility sperm morphology chronic abacterial prostatitis licopid mononuclear cells pathogen-associated molecular patterns Immunologic diseases. Allergy RC581-607 A. V. Semyonov N. Yu. Sotnikova A. A. Martenova EFFICIENCY OF LICOPID IN THE PATIENTS WITH CHRONIC ABACTERIAL PROSTATITIS COMPLICATED WITH FERTILITY DISORDERS
description	Abstract. The study was aimed for evaluation of clinical and immunological efficiency of an immunomodulating drug Licopid (Peptec «CJSC») in chronic abacterial prostatitis (CAP) accompanied by fertility alterations. Licopid contains N-acetylglucoseaminil-β1-4-acetylmuramoyl-L-alanyl-D-isoglutamine (GMDP) which mimics a minimal repeated peptidoglycan structural unit from bacterial cell wall, and it represents a pathogen-associated molecular pattern, able to influence the innate immune system via appropriate pattern-recognition receptors. Thirty-eight infertile patients with azoospermia were under observation (20 to 45 years old, a mean of 28.84±1.1). CAP was diagnosed in accordance with NIH criteria, as chronic prostatitis of III-A category. Clinical examination included sperm analysis, using WHO criteria, and phenotyping of peripheral blood mononuclear cells, by the means of standard flow cytometry (FACScan, «Becton Dickinson»). A control group consisted of eight fertile males 21 to 33 years old (a mean of 26.8±2.33) with normozoospermia. For twenty-four randomly selected patients (main group), a treatment with Licopid was applied (a total of 100 mg, at a daily oral dose of 10 mg), in addition to common therapeutic schedule (fluorochinolones, α-adrenoblockers). A comparison group included fourteen patients receiving common therapy. Some differences in immune response were detectable in the CAP patients. Along with balanced («intense») state of immunity revealed in 16 subjects, 22 persons did exhibit a systemic immunosuppression which manifested as alterations in MNC activation and decreasing efficiency of the standard treatment. Licopid seems to be a drug of choice for these cases, due to decreased CAP activity and normalization of a spermogram following its application. Differentiated administration of immune modulating drugs will allow prevention of adverse effects of empirical immunocorrection.
format	article
author	A. V. Semyonov N. Yu. Sotnikova A. A. Martenova
author_facet	A. V. Semyonov N. Yu. Sotnikova A. A. Martenova
author_sort	A. V. Semyonov
title	EFFICIENCY OF LICOPID IN THE PATIENTS WITH CHRONIC ABACTERIAL PROSTATITIS COMPLICATED WITH FERTILITY DISORDERS
title_short	EFFICIENCY OF LICOPID IN THE PATIENTS WITH CHRONIC ABACTERIAL PROSTATITIS COMPLICATED WITH FERTILITY DISORDERS
title_full	EFFICIENCY OF LICOPID IN THE PATIENTS WITH CHRONIC ABACTERIAL PROSTATITIS COMPLICATED WITH FERTILITY DISORDERS
title_fullStr	EFFICIENCY OF LICOPID IN THE PATIENTS WITH CHRONIC ABACTERIAL PROSTATITIS COMPLICATED WITH FERTILITY DISORDERS
title_full_unstemmed	EFFICIENCY OF LICOPID IN THE PATIENTS WITH CHRONIC ABACTERIAL PROSTATITIS COMPLICATED WITH FERTILITY DISORDERS
title_sort	efficiency of licopid in the patients with chronic abacterial prostatitis complicated with fertility disorders
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/f6a95183a128439195ebe2e02f3ea69f
work_keys_str_mv	AT avsemyonov efficiencyoflicopidinthepatientswithchronicabacterialprostatitiscomplicatedwithfertilitydisorders AT nyusotnikova efficiencyoflicopidinthepatientswithchronicabacterialprostatitiscomplicatedwithfertilitydisorders AT aamartenova efficiencyoflicopidinthepatientswithchronicabacterialprostatitiscomplicatedwithfertilitydisorders
_version_	1718422581062664192

EFFICIENCY OF LICOPID IN THE PATIENTS WITH CHRONIC ABACTERIAL PROSTATITIS COMPLICATED WITH FERTILITY DISORDERS

Ejemplares similares