BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage checkpoint signaling in oncogenic cells.

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Detalles Bibliográficos
Autores principales:	Fred C. Lam, Yi Wen Kong, Qiuying Huang, Tu-Lan Vu Han, Amanda D. Maffa, Ekkehard M. Kasper, Michael B. Yaffe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6a993f462d34f85a100211de5c5cdd7
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spelling	oai:doaj.org-article:f6a993f462d34f85a100211de5c5cdd72021-12-02T16:27:56ZBRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage10.1038/s41467-020-17503-y2041-1723https://doaj.org/article/f6a993f462d34f85a100211de5c5cdd72020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17503-yhttps://doaj.org/toc/2041-1723In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage checkpoint signaling in oncogenic cells.Fred C. LamYi Wen KongQiuying HuangTu-Lan Vu HanAmanda D. MaffaEkkehard M. KasperMichael B. YaffeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fred C. Lam Yi Wen Kong Qiuying Huang Tu-Lan Vu Han Amanda D. Maffa Ekkehard M. Kasper Michael B. Yaffe BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
description	In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage checkpoint signaling in oncogenic cells.
format	article
author	Fred C. Lam Yi Wen Kong Qiuying Huang Tu-Lan Vu Han Amanda D. Maffa Ekkehard M. Kasper Michael B. Yaffe
author_facet	Fred C. Lam Yi Wen Kong Qiuying Huang Tu-Lan Vu Han Amanda D. Maffa Ekkehard M. Kasper Michael B. Yaffe
author_sort	Fred C. Lam
title	BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
title_short	BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
title_full	BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
title_fullStr	BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
title_full_unstemmed	BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
title_sort	brd4 prevents the accumulation of r-loops and protects against transcription–replication collision events and dna damage
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f6a993f462d34f85a100211de5c5cdd7
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BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

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