Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides
Fluoroalkyl groups are widely found in pharmaceutical products. Here, the authors report a highly enantioselective nickel-catalyzed cross coupling method for the construction of fluoromethylated stereogenic centers via a highly reactive zincate species facilitating the transmetalation step in the ni...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/f6a9bb3ae5b44bb2b06515ade57872cb |
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| Sumario: | Fluoroalkyl groups are widely found in pharmaceutical products. Here, the authors report a highly enantioselective nickel-catalyzed cross coupling method for the construction of fluoromethylated stereogenic centers via a highly reactive zincate species facilitating the transmetalation step in the nickel catalytic cycle. |
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