Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides

Fluoroalkyl groups are widely found in pharmaceutical products. Here, the authors report a highly enantioselective nickel-catalyzed cross coupling method for the construction of fluoromethylated stereogenic centers via a highly reactive zincate species facilitating the transmetalation step in the ni...

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Autores principales:	Weichen Huang, Mei Hu, Xiaolong Wan, Qilong Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6a9bb3ae5b44bb2b06515ade57872cb
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spelling	oai:doaj.org-article:f6a9bb3ae5b44bb2b06515ade57872cb2021-12-02T16:57:32ZFacilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides10.1038/s41467-019-10851-42041-1723https://doaj.org/article/f6a9bb3ae5b44bb2b06515ade57872cb2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10851-4https://doaj.org/toc/2041-1723Fluoroalkyl groups are widely found in pharmaceutical products. Here, the authors report a highly enantioselective nickel-catalyzed cross coupling method for the construction of fluoromethylated stereogenic centers via a highly reactive zincate species facilitating the transmetalation step in the nickel catalytic cycle.Weichen HuangMei HuXiaolong WanQilong ShenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weichen Huang Mei Hu Xiaolong Wan Qilong Shen Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides
description	Fluoroalkyl groups are widely found in pharmaceutical products. Here, the authors report a highly enantioselective nickel-catalyzed cross coupling method for the construction of fluoromethylated stereogenic centers via a highly reactive zincate species facilitating the transmetalation step in the nickel catalytic cycle.
format	article
author	Weichen Huang Mei Hu Xiaolong Wan Qilong Shen
author_facet	Weichen Huang Mei Hu Xiaolong Wan Qilong Shen
author_sort	Weichen Huang
title	Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides
title_short	Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides
title_full	Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides
title_fullStr	Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides
title_full_unstemmed	Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides
title_sort	facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f6a9bb3ae5b44bb2b06515ade57872cb
work_keys_str_mv	AT weichenhuang facilitatingthetransmetalationstepwitharylzincatesinnickelcatalyzedenantioselectivearylationofsecondarybenzylichalides AT meihu facilitatingthetransmetalationstepwitharylzincatesinnickelcatalyzedenantioselectivearylationofsecondarybenzylichalides AT xiaolongwan facilitatingthetransmetalationstepwitharylzincatesinnickelcatalyzedenantioselectivearylationofsecondarybenzylichalides AT qilongshen facilitatingthetransmetalationstepwitharylzincatesinnickelcatalyzedenantioselectivearylationofsecondarybenzylichalides
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Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides

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