Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians

Abstract Superoxide dismutase 3 (SOD3), an antioxidant enzyme, is known as extracellular SOD (EC-SOD) because it is the predominant form in extracellular fluids. The diversity of plasma EC-SOD concentration is associated with the SOD3 p.R231G missense variant genotype. To clarify the association amo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takashi Sasaki, Yukiko Abe, Michiyo Takayama, Tetsuo Adachi, Hideyuki Okano, Nobuyoshi Hirose, Yasumichi Arai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6aace1d27794f70b250f0c94ed53c3c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f6aace1d27794f70b250f0c94ed53c3c
record_format	dspace
spelling	oai:doaj.org-article:f6aace1d27794f70b250f0c94ed53c3c2021-12-02T13:39:23ZAssociation among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians10.1038/s41598-021-87982-62045-2322https://doaj.org/article/f6aace1d27794f70b250f0c94ed53c3c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87982-6https://doaj.org/toc/2045-2322Abstract Superoxide dismutase 3 (SOD3), an antioxidant enzyme, is known as extracellular SOD (EC-SOD) because it is the predominant form in extracellular fluids. The diversity of plasma EC-SOD concentration is associated with the SOD3 p.R231G missense variant genotype. To clarify the association among SOD3 genotype, plasma EC-SOD concentration, and comorbidity in Oldest Old, we analyzed genome-wide associations with plasma EC-SOD concentration and associations between EC-SOD concentration and medical history classified by the SOD3 genotype in the Very Old (85–99 years old, n = 505) and Centenarians (over 100 years old, n = 595). The results revealed that SOD3 p.R231G was the most significant variant associated with plasma EC-SOD concentration. Although no significant difference was observed in medical histories between the SOD3 p.R231G variant non-carriers and carriers, higher EC-SOD concentration in plasma of SOD3 p.R231G variant non-carriers was associated with a high odds ratio for chronic kidney disease (OR = 2.70, 95% CI = 1.98–3.72) and low odds ratio for diabetes mellitus (DM) (OR = 0.61, 95% CI = 0.39–0.95). Comparison with 11 plasma biomarkers for age-related disease showed that plasma EC-SOD concentration correlated with adiponectin and estimated glomerular filtration rate with creatinine correction; therefore, we deduced that EC-SOD co-operates with adiponectin and possesses beneficial functions for DM in the Oldest Old.Takashi SasakiYukiko AbeMichiyo TakayamaTetsuo AdachiHideyuki OkanoNobuyoshi HiroseYasumichi AraiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takashi Sasaki Yukiko Abe Michiyo Takayama Tetsuo Adachi Hideyuki Okano Nobuyoshi Hirose Yasumichi Arai Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
description	Abstract Superoxide dismutase 3 (SOD3), an antioxidant enzyme, is known as extracellular SOD (EC-SOD) because it is the predominant form in extracellular fluids. The diversity of plasma EC-SOD concentration is associated with the SOD3 p.R231G missense variant genotype. To clarify the association among SOD3 genotype, plasma EC-SOD concentration, and comorbidity in Oldest Old, we analyzed genome-wide associations with plasma EC-SOD concentration and associations between EC-SOD concentration and medical history classified by the SOD3 genotype in the Very Old (85–99 years old, n = 505) and Centenarians (over 100 years old, n = 595). The results revealed that SOD3 p.R231G was the most significant variant associated with plasma EC-SOD concentration. Although no significant difference was observed in medical histories between the SOD3 p.R231G variant non-carriers and carriers, higher EC-SOD concentration in plasma of SOD3 p.R231G variant non-carriers was associated with a high odds ratio for chronic kidney disease (OR = 2.70, 95% CI = 1.98–3.72) and low odds ratio for diabetes mellitus (DM) (OR = 0.61, 95% CI = 0.39–0.95). Comparison with 11 plasma biomarkers for age-related disease showed that plasma EC-SOD concentration correlated with adiponectin and estimated glomerular filtration rate with creatinine correction; therefore, we deduced that EC-SOD co-operates with adiponectin and possesses beneficial functions for DM in the Oldest Old.
format	article
author	Takashi Sasaki Yukiko Abe Michiyo Takayama Tetsuo Adachi Hideyuki Okano Nobuyoshi Hirose Yasumichi Arai
author_facet	Takashi Sasaki Yukiko Abe Michiyo Takayama Tetsuo Adachi Hideyuki Okano Nobuyoshi Hirose Yasumichi Arai
author_sort	Takashi Sasaki
title	Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
title_short	Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
title_full	Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
title_fullStr	Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
title_full_unstemmed	Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
title_sort	association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f6aace1d27794f70b250f0c94ed53c3c
work_keys_str_mv	AT takashisasaki associationamongextracellularsuperoxidedismutasegenotypeplasmaconcentrationandcomorbidityintheveryoldandcentenarians AT yukikoabe associationamongextracellularsuperoxidedismutasegenotypeplasmaconcentrationandcomorbidityintheveryoldandcentenarians AT michiyotakayama associationamongextracellularsuperoxidedismutasegenotypeplasmaconcentrationandcomorbidityintheveryoldandcentenarians AT tetsuoadachi associationamongextracellularsuperoxidedismutasegenotypeplasmaconcentrationandcomorbidityintheveryoldandcentenarians AT hideyukiokano associationamongextracellularsuperoxidedismutasegenotypeplasmaconcentrationandcomorbidityintheveryoldandcentenarians AT nobuyoshihirose associationamongextracellularsuperoxidedismutasegenotypeplasmaconcentrationandcomorbidityintheveryoldandcentenarians AT yasumichiarai associationamongextracellularsuperoxidedismutasegenotypeplasmaconcentrationandcomorbidityintheveryoldandcentenarians
_version_	1718392652931530752

Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians

Ejemplares similares