Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization

Bone tissue is a complex organic-inorganic nanocomposite and strategies that replicate the characteristics of bone tissue are scarce. Here the authors demonstrate the deposition of nanoscale apatite in collagen embedded with mesenchymal, vascular and nerve cells, using a protein-guided biomineraliza...

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Autores principales:	Greeshma Thrivikraman, Avathamsa Athirasala, Ryan Gordon, Limin Zhang, Raymond Bergan, Douglas R. Keene, James M. Jones, Hua Xie, Zhiqiang Chen, Jinhui Tao, Brian Wingender, Laurie Gower, Jack L. Ferracane, Luiz E. Bertassoni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6ac760f1ff1481e87fd77e0b3a8f00f
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spelling	oai:doaj.org-article:f6ac760f1ff1481e87fd77e0b3a8f00f2021-12-02T14:35:37ZRapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization10.1038/s41467-019-11455-82041-1723https://doaj.org/article/f6ac760f1ff1481e87fd77e0b3a8f00f2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11455-8https://doaj.org/toc/2041-1723Bone tissue is a complex organic-inorganic nanocomposite and strategies that replicate the characteristics of bone tissue are scarce. Here the authors demonstrate the deposition of nanoscale apatite in collagen embedded with mesenchymal, vascular and nerve cells, using a protein-guided biomineralization approach.Greeshma ThrivikramanAvathamsa AthirasalaRyan GordonLimin ZhangRaymond BerganDouglas R. KeeneJames M. JonesHua XieZhiqiang ChenJinhui TaoBrian WingenderLaurie GowerJack L. FerracaneLuiz E. BertassoniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Greeshma Thrivikraman Avathamsa Athirasala Ryan Gordon Limin Zhang Raymond Bergan Douglas R. Keene James M. Jones Hua Xie Zhiqiang Chen Jinhui Tao Brian Wingender Laurie Gower Jack L. Ferracane Luiz E. Bertassoni Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization
description	Bone tissue is a complex organic-inorganic nanocomposite and strategies that replicate the characteristics of bone tissue are scarce. Here the authors demonstrate the deposition of nanoscale apatite in collagen embedded with mesenchymal, vascular and nerve cells, using a protein-guided biomineralization approach.
format	article
author	Greeshma Thrivikraman Avathamsa Athirasala Ryan Gordon Limin Zhang Raymond Bergan Douglas R. Keene James M. Jones Hua Xie Zhiqiang Chen Jinhui Tao Brian Wingender Laurie Gower Jack L. Ferracane Luiz E. Bertassoni
author_facet	Greeshma Thrivikraman Avathamsa Athirasala Ryan Gordon Limin Zhang Raymond Bergan Douglas R. Keene James M. Jones Hua Xie Zhiqiang Chen Jinhui Tao Brian Wingender Laurie Gower Jack L. Ferracane Luiz E. Bertassoni
author_sort	Greeshma Thrivikraman
title	Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization
title_short	Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization
title_full	Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization
title_fullStr	Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization
title_full_unstemmed	Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization
title_sort	rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f6ac760f1ff1481e87fd77e0b3a8f00f
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Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization

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