HSP-90/kinase complexes are stabilized by the large PPIase FKB-6

HSP-90/kinase complexes are stabilized by the large PPIase FKB-6

Abstract Protein kinases are important regulators in cellular signal transduction. As one major type of Hsp90 client, protein kinases rely on the ATP-dependent molecular chaperone Hsp90, which maintains their structure and supports their activation. Depending on client type, Hsp90 interacts with dif...

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Autores principales: Siyuan Sima, Katalin Barkovits, Katrin Marcus, Lukas Schmauder, Stephan M. Hacker, Nils Hellwig, Nina Morgner, Klaus Richter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/f6aca38767d14b3994c3215e5e2f658e
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