A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.

Toxin-antitoxin (TA) modules are gene pairs specifying for a toxin and its antitoxin and are found on the chromosomes of many bacteria including pathogens. Here we report how each of five such TA systems in E. coli affect bacterial cell death differently in liquid media and during biofilm formation....

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Autores principales:	Ilana Kolodkin-Gal, Reut Verdiger, Ayalla Shlosberg-Fedida, Hanna Engelberg-Kulka
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6b01d7139cd4e92a6028a497f39fdaa
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spelling	oai:doaj.org-article:f6b01d7139cd4e92a6028a497f39fdaa2021-11-25T06:20:48ZA differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.1932-620310.1371/journal.pone.0006785https://doaj.org/article/f6b01d7139cd4e92a6028a497f39fdaa2009-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19707553/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Toxin-antitoxin (TA) modules are gene pairs specifying for a toxin and its antitoxin and are found on the chromosomes of many bacteria including pathogens. Here we report how each of five such TA systems in E. coli affect bacterial cell death differently in liquid media and during biofilm formation. Of all these systems, only the TA system mazEF mediated cell death both in liquid media and during biofilm formation. At the other extreme, as our results have revealed here, the TA system dinJ-YafQ is unique in that it is involved only in the death process during biofilm formation. Cell death governed by mazEF and dinJ-YafQ seems to participate in biofilm formation through a novel mechanism.Ilana Kolodkin-GalReut VerdigerAyalla Shlosberg-FedidaHanna Engelberg-KulkaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 8, p e6785 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ilana Kolodkin-Gal Reut Verdiger Ayalla Shlosberg-Fedida Hanna Engelberg-Kulka A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.
description	Toxin-antitoxin (TA) modules are gene pairs specifying for a toxin and its antitoxin and are found on the chromosomes of many bacteria including pathogens. Here we report how each of five such TA systems in E. coli affect bacterial cell death differently in liquid media and during biofilm formation. Of all these systems, only the TA system mazEF mediated cell death both in liquid media and during biofilm formation. At the other extreme, as our results have revealed here, the TA system dinJ-YafQ is unique in that it is involved only in the death process during biofilm formation. Cell death governed by mazEF and dinJ-YafQ seems to participate in biofilm formation through a novel mechanism.
format	article
author	Ilana Kolodkin-Gal Reut Verdiger Ayalla Shlosberg-Fedida Hanna Engelberg-Kulka
author_facet	Ilana Kolodkin-Gal Reut Verdiger Ayalla Shlosberg-Fedida Hanna Engelberg-Kulka
author_sort	Ilana Kolodkin-Gal
title	A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.
title_short	A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.
title_full	A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.
title_fullStr	A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.
title_full_unstemmed	A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.
title_sort	differential effect of e. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/f6b01d7139cd4e92a6028a497f39fdaa
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A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.

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