Nano Zinc Oxide Green-Synthesized from <i>Plumbago auriculata</i> Lam. Alcoholic Extract

Zinc oxide nanoparticles (ZnO NPs) were synthesized by using an alcoholic extract of the flowering aerial parts of <i>Plumbago auriculata</i> Lam. Dynamic Light Scattering (DLS) revealed that the average size of synthesized ZnO NPs was 10.58 ± 3.350 nm and the zeta potential was −19.6 mV...

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Autores principales:	Mina Michael Melk, Seham S. El-Hawary, Farouk Rasmy Melek, Dalia Osama Saleh, Omar M. Ali, Mohamed A. El Raey, Nabil Mohamed Selim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ZnO NPs <i>Plumbago auriculata</i> Lam. HPLC analysis antiviral activity green synthesis Botany QK1-989
Acceso en línea:	https://doaj.org/article/f6b1796feafd40a0a311095a44802da7
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spelling	oai:doaj.org-article:f6b1796feafd40a0a311095a44802da72021-11-25T18:46:40ZNano Zinc Oxide Green-Synthesized from <i>Plumbago auriculata</i> Lam. Alcoholic Extract10.3390/plants101124472223-7747https://doaj.org/article/f6b1796feafd40a0a311095a44802da72021-11-01T00:00:00Zhttps://www.mdpi.com/2223-7747/10/11/2447https://doaj.org/toc/2223-7747Zinc oxide nanoparticles (ZnO NPs) were synthesized by using an alcoholic extract of the flowering aerial parts of <i>Plumbago auriculata</i> Lam. Dynamic Light Scattering (DLS) revealed that the average size of synthesized ZnO NPs was 10.58 ± 3.350 nm and the zeta potential was −19.6 mV. Transmission electron microscopy (TEM) revealed that the particle size was in the range from 5.08 to 6.56 nm. X-ray diffraction (XRD) analysis verified the existence of pure hexagonal shaped crystals of ZnO nanoparticles with an average size of 35.34 nm in the sample, which is similar to the particle size analysis acquired by scanning electron microscopy (SEM) (38.29 ± 6.88 nm). HPLC analysis of the phenolic ingredients present in the plant extract showed that gallic acid, chlorogenic acid, and catechin were found as major compounds at concentrations of 1720.26, 1600.42, and 840.20 µg/g, respectively. Furthermore, the inhibitory effects of ZnO NPs and the plant extract against avian metapneumovirus (aMPV) subtype B were also investigated. This assessment revealed that the uncalcinated form of Nano-ZnO mediated by <i>P. auriculata</i> Lam. extract possessed a significant antiviral activity with 50% cytotoxic concentration (CC<sub>50</sub>) and 50% inhibition concentration (IC<sub>50</sub>) of 52.48 ± 1.57 and 42.67 ± 4.08 µg/mL, respectively, while the inhibition percentage (IP) was 99% and the selectivity index (SI) was 1.23.Mina Michael MelkSeham S. El-HawaryFarouk Rasmy MelekDalia Osama SalehOmar M. AliMohamed A. El RaeyNabil Mohamed SelimMDPI AGarticleZnO NPs<i>Plumbago auriculata</i> Lam.HPLC analysisantiviral activitygreen synthesisBotanyQK1-989ENPlants, Vol 10, Iss 2447, p 2447 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ZnO NPs <i>Plumbago auriculata</i> Lam. HPLC analysis antiviral activity green synthesis Botany QK1-989
spellingShingle	ZnO NPs <i>Plumbago auriculata</i> Lam. HPLC analysis antiviral activity green synthesis Botany QK1-989 Mina Michael Melk Seham S. El-Hawary Farouk Rasmy Melek Dalia Osama Saleh Omar M. Ali Mohamed A. El Raey Nabil Mohamed Selim Nano Zinc Oxide Green-Synthesized from <i>Plumbago auriculata</i> Lam. Alcoholic Extract
description	Zinc oxide nanoparticles (ZnO NPs) were synthesized by using an alcoholic extract of the flowering aerial parts of <i>Plumbago auriculata</i> Lam. Dynamic Light Scattering (DLS) revealed that the average size of synthesized ZnO NPs was 10.58 ± 3.350 nm and the zeta potential was −19.6 mV. Transmission electron microscopy (TEM) revealed that the particle size was in the range from 5.08 to 6.56 nm. X-ray diffraction (XRD) analysis verified the existence of pure hexagonal shaped crystals of ZnO nanoparticles with an average size of 35.34 nm in the sample, which is similar to the particle size analysis acquired by scanning electron microscopy (SEM) (38.29 ± 6.88 nm). HPLC analysis of the phenolic ingredients present in the plant extract showed that gallic acid, chlorogenic acid, and catechin were found as major compounds at concentrations of 1720.26, 1600.42, and 840.20 µg/g, respectively. Furthermore, the inhibitory effects of ZnO NPs and the plant extract against avian metapneumovirus (aMPV) subtype B were also investigated. This assessment revealed that the uncalcinated form of Nano-ZnO mediated by <i>P. auriculata</i> Lam. extract possessed a significant antiviral activity with 50% cytotoxic concentration (CC<sub>50</sub>) and 50% inhibition concentration (IC<sub>50</sub>) of 52.48 ± 1.57 and 42.67 ± 4.08 µg/mL, respectively, while the inhibition percentage (IP) was 99% and the selectivity index (SI) was 1.23.
format	article
author	Mina Michael Melk Seham S. El-Hawary Farouk Rasmy Melek Dalia Osama Saleh Omar M. Ali Mohamed A. El Raey Nabil Mohamed Selim
author_facet	Mina Michael Melk Seham S. El-Hawary Farouk Rasmy Melek Dalia Osama Saleh Omar M. Ali Mohamed A. El Raey Nabil Mohamed Selim
author_sort	Mina Michael Melk
title	Nano Zinc Oxide Green-Synthesized from <i>Plumbago auriculata</i> Lam. Alcoholic Extract
title_short	Nano Zinc Oxide Green-Synthesized from <i>Plumbago auriculata</i> Lam. Alcoholic Extract
title_full	Nano Zinc Oxide Green-Synthesized from <i>Plumbago auriculata</i> Lam. Alcoholic Extract
title_fullStr	Nano Zinc Oxide Green-Synthesized from <i>Plumbago auriculata</i> Lam. Alcoholic Extract
title_full_unstemmed	Nano Zinc Oxide Green-Synthesized from <i>Plumbago auriculata</i> Lam. Alcoholic Extract
title_sort	nano zinc oxide green-synthesized from <i>plumbago auriculata</i> lam. alcoholic extract
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f6b1796feafd40a0a311095a44802da7
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Nano Zinc Oxide Green-Synthesized from <i>Plumbago auriculata</i> Lam. Alcoholic Extract

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