Design, synthesis, and biological evaluation of novel triazoloquinazolinone derivatives as SHP2 protein inhibitors

A novel series of triazoloquinazolinone derivatives were designed, synthesised, and evaluated for their in vitro biological activities against the SHP2 protein. Moreover, some compounds were evaluated against A375 cells. The results revealed that target compounds possessed moderate to excellent inhi...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Rongshuang Luo, Zhongyuan Wang, Dali Luo, Yumei Qin, Chunshen Zhao, Di Yang, Tian Lu, Zhixu Zhou, Zhuyan Huang
Format: article
Langue:EN
Publié: Taylor & Francis Group 2021
Sujets:
Accès en ligne:https://doaj.org/article/f6b4e6f2b10c48e0b8e1d41569278350
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!