Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity

Glial engulfment declines with age, but the mechanism is unclear. Here authors show that in the Drosophilaolfactory system, glial phagocytosis of injury-induced degenerating axons decreases with age due to reduced PI3K/Draper activity, and restoring Draper in aged glia rescues such defects.

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria D. Purice, Sean D. Speese, Mary A. Logan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6b672af42684873a638cdf9f9fd3158
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f6b672af42684873a638cdf9f9fd3158
record_format	dspace
spelling	oai:doaj.org-article:f6b672af42684873a638cdf9f9fd31582021-12-02T15:35:21ZDelayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity10.1038/ncomms128712041-1723https://doaj.org/article/f6b672af42684873a638cdf9f9fd31582016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12871https://doaj.org/toc/2041-1723Glial engulfment declines with age, but the mechanism is unclear. Here authors show that in the Drosophilaolfactory system, glial phagocytosis of injury-induced degenerating axons decreases with age due to reduced PI3K/Draper activity, and restoring Draper in aged glia rescues such defects.Maria D. PuriceSean D. SpeeseMary A. LoganNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria D. Purice Sean D. Speese Mary A. Logan Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity
description	Glial engulfment declines with age, but the mechanism is unclear. Here authors show that in the Drosophilaolfactory system, glial phagocytosis of injury-induced degenerating axons decreases with age due to reduced PI3K/Draper activity, and restoring Draper in aged glia rescues such defects.
format	article
author	Maria D. Purice Sean D. Speese Mary A. Logan
author_facet	Maria D. Purice Sean D. Speese Mary A. Logan
author_sort	Maria D. Purice
title	Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity
title_short	Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity
title_full	Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity
title_fullStr	Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity
title_full_unstemmed	Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity
title_sort	delayed glial clearance of degenerating axons in aged drosophila is due to reduced pi3k/draper activity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f6b672af42684873a638cdf9f9fd3158
work_keys_str_mv	AT mariadpurice delayedglialclearanceofdegeneratingaxonsinageddrosophilaisduetoreducedpi3kdraperactivity AT seandspeese delayedglialclearanceofdegeneratingaxonsinageddrosophilaisduetoreducedpi3kdraperactivity AT maryalogan delayedglialclearanceofdegeneratingaxonsinageddrosophilaisduetoreducedpi3kdraperactivity
_version_	1718386633729900544

Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity

Ejemplares similares