Bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study

Abstract Background Blood stream infections are serious infections that usually induce prolongation of hospital stay, morbidity and mortality in several countries including Ethiopia. The aim of this study was to determine bacterial and fungal profile, their drug resistance patterns, and risk factors...

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Autores principales:	Etsehiwot Adamu Tsegaye, Dejenie Shiferaw Teklu, Zelalem Tazu Bonger, Abebe Aseffa Negeri, Tesfaye Legesse Bedada, Adane Bitew
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Blood stream infections Bacterial and fungal profile Antimicrobial resistance pattern Risk factor Ethiopia Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f6b75f03d20242f198a3508d3f09f77c
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spelling	oai:doaj.org-article:f6b75f03d20242f198a3508d3f09f77c2021-12-05T12:26:07ZBacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study10.1186/s12879-021-06896-w1471-2334https://doaj.org/article/f6b75f03d20242f198a3508d3f09f77c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06896-whttps://doaj.org/toc/1471-2334Abstract Background Blood stream infections are serious infections that usually induce prolongation of hospital stay, morbidity and mortality in several countries including Ethiopia. The aim of this study was to determine bacterial and fungal profile, their drug resistance patterns, and risk factors associated with blood stream infections. Methods A cross sectional study design was conducted from February 23 to June 23, 2020 at Ethiopian public health. A structured questionnaire was used to collect data on socio-demographic factors and clinical conditions. Blood specimens were analyzed using standard microbiological techniques. Antimicrobial susceptibility tests were performed using Kirby–Bauer disc diffusion technique and Vitek compact 2. Simple and multiple logistic regressions were used to assess the potential risk factors. Results A total of 175 pathogens isolated from 346 blood specimens. Of these, 60% Gram-negative bacteria, 30.86% Gram-positive bacteria and 9.14% fungal isolates were identified. Burkholderia cepacia and Coagulase negative staphylococcus were the predominant pathogen among Gram-negative and Gram-positive bacteria respectively. Among fungus, Candida krusei (56.25%) was the most predominant isolate. The highest proportions of antibacterial resistance were observed among 3rd generation cephalosporin and penicillin. Most fungal isolates expressed resistance to fluconazole. Sex (P = 0.007), age (P < 0.001) and use of invasive medical devices (P = 0.003) were identified as risk factors for bacterial blood stream infections. Conclusion The study showed high prevalence of blood stream infection was due to B. cepacia and non-C. albicans spp. This finding alarming ongoing investigation of blood stream infection is important for recognizing future potential preventive strategies including environmental hygiene and management of comorbid medical diseases to reduce the problem.Etsehiwot Adamu TsegayeDejenie Shiferaw TekluZelalem Tazu BongerAbebe Aseffa NegeriTesfaye Legesse BedadaAdane BitewBMCarticleBlood stream infectionsBacterial and fungal profileAntimicrobial resistance patternRisk factorEthiopiaInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Blood stream infections Bacterial and fungal profile Antimicrobial resistance pattern Risk factor Ethiopia Infectious and parasitic diseases RC109-216
spellingShingle	Blood stream infections Bacterial and fungal profile Antimicrobial resistance pattern Risk factor Ethiopia Infectious and parasitic diseases RC109-216 Etsehiwot Adamu Tsegaye Dejenie Shiferaw Teklu Zelalem Tazu Bonger Abebe Aseffa Negeri Tesfaye Legesse Bedada Adane Bitew Bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study
description	Abstract Background Blood stream infections are serious infections that usually induce prolongation of hospital stay, morbidity and mortality in several countries including Ethiopia. The aim of this study was to determine bacterial and fungal profile, their drug resistance patterns, and risk factors associated with blood stream infections. Methods A cross sectional study design was conducted from February 23 to June 23, 2020 at Ethiopian public health. A structured questionnaire was used to collect data on socio-demographic factors and clinical conditions. Blood specimens were analyzed using standard microbiological techniques. Antimicrobial susceptibility tests were performed using Kirby–Bauer disc diffusion technique and Vitek compact 2. Simple and multiple logistic regressions were used to assess the potential risk factors. Results A total of 175 pathogens isolated from 346 blood specimens. Of these, 60% Gram-negative bacteria, 30.86% Gram-positive bacteria and 9.14% fungal isolates were identified. Burkholderia cepacia and Coagulase negative staphylococcus were the predominant pathogen among Gram-negative and Gram-positive bacteria respectively. Among fungus, Candida krusei (56.25%) was the most predominant isolate. The highest proportions of antibacterial resistance were observed among 3rd generation cephalosporin and penicillin. Most fungal isolates expressed resistance to fluconazole. Sex (P = 0.007), age (P < 0.001) and use of invasive medical devices (P = 0.003) were identified as risk factors for bacterial blood stream infections. Conclusion The study showed high prevalence of blood stream infection was due to B. cepacia and non-C. albicans spp. This finding alarming ongoing investigation of blood stream infection is important for recognizing future potential preventive strategies including environmental hygiene and management of comorbid medical diseases to reduce the problem.
format	article
author	Etsehiwot Adamu Tsegaye Dejenie Shiferaw Teklu Zelalem Tazu Bonger Abebe Aseffa Negeri Tesfaye Legesse Bedada Adane Bitew
author_facet	Etsehiwot Adamu Tsegaye Dejenie Shiferaw Teklu Zelalem Tazu Bonger Abebe Aseffa Negeri Tesfaye Legesse Bedada Adane Bitew
author_sort	Etsehiwot Adamu Tsegaye
title	Bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study
title_short	Bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study
title_full	Bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study
title_fullStr	Bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study
title_full_unstemmed	Bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study
title_sort	bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to ethiopian public health institute: cross-sectional study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f6b75f03d20242f198a3508d3f09f77c
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Bacterial and fungal profile, drug resistance pattern and associated factors of isolates recovered from blood samples of patients referred to Ethiopian Public Health Institute: cross-sectional study

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