Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

Proteolysis targeting chimeras (PROTACs) is an effective alternative to modulate protein homeostasis but can lead to uncontrollable protein degradation and off-target side effects. Here, the authors developed semiconducting polymer nano-PROTACs with phototherapeutic and activatable protein degradati...

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Autores principales: Chi Zhang, Ziling Zeng, Dong Cui, Shasha He, Yuyan Jiang, Jingchao Li, Jiaguo Huang, Kanyi Pu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f6b826023896477c9ccf92b806a2fbfb
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spelling oai:doaj.org-article:f6b826023896477c9ccf92b806a2fbfb2021-12-02T16:51:29ZSemiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy10.1038/s41467-021-23194-w2041-1723https://doaj.org/article/f6b826023896477c9ccf92b806a2fbfb2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23194-whttps://doaj.org/toc/2041-1723Proteolysis targeting chimeras (PROTACs) is an effective alternative to modulate protein homeostasis but can lead to uncontrollable protein degradation and off-target side effects. Here, the authors developed semiconducting polymer nano-PROTACs with phototherapeutic and activatable protein degradation abilities for photo-immunometabolic cancer therapy.Chi ZhangZiling ZengDong CuiShasha HeYuyan JiangJingchao LiJiaguo HuangKanyi PuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chi Zhang
Ziling Zeng
Dong Cui
Shasha He
Yuyan Jiang
Jingchao Li
Jiaguo Huang
Kanyi Pu
Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy
description Proteolysis targeting chimeras (PROTACs) is an effective alternative to modulate protein homeostasis but can lead to uncontrollable protein degradation and off-target side effects. Here, the authors developed semiconducting polymer nano-PROTACs with phototherapeutic and activatable protein degradation abilities for photo-immunometabolic cancer therapy.
format article
author Chi Zhang
Ziling Zeng
Dong Cui
Shasha He
Yuyan Jiang
Jingchao Li
Jiaguo Huang
Kanyi Pu
author_facet Chi Zhang
Ziling Zeng
Dong Cui
Shasha He
Yuyan Jiang
Jingchao Li
Jiaguo Huang
Kanyi Pu
author_sort Chi Zhang
title Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy
title_short Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy
title_full Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy
title_fullStr Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy
title_full_unstemmed Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy
title_sort semiconducting polymer nano-protacs for activatable photo-immunometabolic cancer therapy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f6b826023896477c9ccf92b806a2fbfb
work_keys_str_mv AT chizhang semiconductingpolymernanoprotacsforactivatablephotoimmunometaboliccancertherapy
AT zilingzeng semiconductingpolymernanoprotacsforactivatablephotoimmunometaboliccancertherapy
AT dongcui semiconductingpolymernanoprotacsforactivatablephotoimmunometaboliccancertherapy
AT shashahe semiconductingpolymernanoprotacsforactivatablephotoimmunometaboliccancertherapy
AT yuyanjiang semiconductingpolymernanoprotacsforactivatablephotoimmunometaboliccancertherapy
AT jingchaoli semiconductingpolymernanoprotacsforactivatablephotoimmunometaboliccancertherapy
AT jiaguohuang semiconductingpolymernanoprotacsforactivatablephotoimmunometaboliccancertherapy
AT kanyipu semiconductingpolymernanoprotacsforactivatablephotoimmunometaboliccancertherapy
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