Ongoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins

Understanding the evolution of viral pathogens is critical to being able to define how viruses emerge within different landscapes. Host susceptibility, which is spread between different species and is a contributing factor to the subsequent epidemiology of a disease, is defined by virus detection an...

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Autores principales:	Mana Mahapatra, Richa Pachauri, Saravanan Subramaniam, Ashley C. Banyard, Shanmugam ChandraSekar, Muthannan Andavar Ramakrishnan, Felix Njeumi, Dhanavelu Muthuchelvan, Satya Parida
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	peste des petits ruminants virus molecular epidemiology evolution lineage divergence full genome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f6bb880b2645432ab4cefa9ef2dd15fa
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spelling	oai:doaj.org-article:f6bb880b2645432ab4cefa9ef2dd15fa2021-11-25T19:12:42ZOngoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins10.3390/v131121441999-4915https://doaj.org/article/f6bb880b2645432ab4cefa9ef2dd15fa2021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2144https://doaj.org/toc/1999-4915Understanding the evolution of viral pathogens is critical to being able to define how viruses emerge within different landscapes. Host susceptibility, which is spread between different species and is a contributing factor to the subsequent epidemiology of a disease, is defined by virus detection and subsequent characterization. Peste des petits ruminants virus is a plague of small ruminant species that is a considerable burden to the development of sustainable agriculture across Africa and much of Asia. The virus has also had a significant impact on populations of endangered species in recent years, highlighting its significance as a pathogen of high concern across different regions of the globe. Here, we have re-evaluated the molecular evolution of this virus using novel genetic data to try and further resolve the molecular epidemiology of this disease. Viral isolates are genetically characterized into four lineages (I−IV), and the historic origin of these lineages is of considerable interest to the molecular evolution of the virus. Our re-evaluation of viral emergence using novel genome sequences has demonstrated that lineages I, II and IV likely originated in West Africa, in Senegal (I) and Nigeria (II and IV). Lineage III sequences predicted emergence in either East Africa (Ethiopia) or in the Arabian Peninsula (Oman and/or the United Arab Emirates), with a paucity of data precluding a more refined interpretation. Continual refinements of evolutionary emergence, following the generation of new data, is key to both understanding viral evolution from a historic perspective and informing on the ongoing genetic emergence of this virus.Mana MahapatraRicha PachauriSaravanan SubramaniamAshley C. BanyardShanmugam ChandraSekarMuthannan Andavar RamakrishnanFelix NjeumiDhanavelu MuthuchelvanSatya ParidaMDPI AGarticlepeste des petits ruminants virusmolecular epidemiologyevolutionlineage divergencefull genomeMicrobiologyQR1-502ENViruses, Vol 13, Iss 2144, p 2144 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	peste des petits ruminants virus molecular epidemiology evolution lineage divergence full genome Microbiology QR1-502
spellingShingle	peste des petits ruminants virus molecular epidemiology evolution lineage divergence full genome Microbiology QR1-502 Mana Mahapatra Richa Pachauri Saravanan Subramaniam Ashley C. Banyard Shanmugam ChandraSekar Muthannan Andavar Ramakrishnan Felix Njeumi Dhanavelu Muthuchelvan Satya Parida Ongoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins
description	Understanding the evolution of viral pathogens is critical to being able to define how viruses emerge within different landscapes. Host susceptibility, which is spread between different species and is a contributing factor to the subsequent epidemiology of a disease, is defined by virus detection and subsequent characterization. Peste des petits ruminants virus is a plague of small ruminant species that is a considerable burden to the development of sustainable agriculture across Africa and much of Asia. The virus has also had a significant impact on populations of endangered species in recent years, highlighting its significance as a pathogen of high concern across different regions of the globe. Here, we have re-evaluated the molecular evolution of this virus using novel genetic data to try and further resolve the molecular epidemiology of this disease. Viral isolates are genetically characterized into four lineages (I−IV), and the historic origin of these lineages is of considerable interest to the molecular evolution of the virus. Our re-evaluation of viral emergence using novel genome sequences has demonstrated that lineages I, II and IV likely originated in West Africa, in Senegal (I) and Nigeria (II and IV). Lineage III sequences predicted emergence in either East Africa (Ethiopia) or in the Arabian Peninsula (Oman and/or the United Arab Emirates), with a paucity of data precluding a more refined interpretation. Continual refinements of evolutionary emergence, following the generation of new data, is key to both understanding viral evolution from a historic perspective and informing on the ongoing genetic emergence of this virus.
format	article
author	Mana Mahapatra Richa Pachauri Saravanan Subramaniam Ashley C. Banyard Shanmugam ChandraSekar Muthannan Andavar Ramakrishnan Felix Njeumi Dhanavelu Muthuchelvan Satya Parida
author_facet	Mana Mahapatra Richa Pachauri Saravanan Subramaniam Ashley C. Banyard Shanmugam ChandraSekar Muthannan Andavar Ramakrishnan Felix Njeumi Dhanavelu Muthuchelvan Satya Parida
author_sort	Mana Mahapatra
title	Ongoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins
title_short	Ongoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins
title_full	Ongoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins
title_fullStr	Ongoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins
title_full_unstemmed	Ongoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins
title_sort	ongoing assessment of the molecular evolution of peste des petits ruminants virus continues to question viral origins
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f6bb880b2645432ab4cefa9ef2dd15fa
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Ongoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins

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