Inherently confinable split-drive systems in Drosophila

NHEJ alleles and Cas9 remnants after a gene drive introduction are scientific and public concerns. Here, the authors use split drives with recoded rescue elements to target essential genes and minimize the appearance of NHEJ alleles while also leaving no trace of Cas9.

Guardado en:

Detalles Bibliográficos
Autores principales:	Gerard Terradas, Anna B. Buchman, Jared B. Bennett, Isaiah Shriner, John M. Marshall, Omar S. Akbari, Ethan Bier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6bec46693bd4699adc26f312c9e760c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f6bec46693bd4699adc26f312c9e760c
record_format	dspace
spelling	oai:doaj.org-article:f6bec46693bd4699adc26f312c9e760c2021-12-02T13:14:48ZInherently confinable split-drive systems in Drosophila10.1038/s41467-021-21771-72041-1723https://doaj.org/article/f6bec46693bd4699adc26f312c9e760c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21771-7https://doaj.org/toc/2041-1723NHEJ alleles and Cas9 remnants after a gene drive introduction are scientific and public concerns. Here, the authors use split drives with recoded rescue elements to target essential genes and minimize the appearance of NHEJ alleles while also leaving no trace of Cas9.Gerard TerradasAnna B. BuchmanJared B. BennettIsaiah ShrinerJohn M. MarshallOmar S. AkbariEthan BierNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gerard Terradas Anna B. Buchman Jared B. Bennett Isaiah Shriner John M. Marshall Omar S. Akbari Ethan Bier Inherently confinable split-drive systems in Drosophila
description	NHEJ alleles and Cas9 remnants after a gene drive introduction are scientific and public concerns. Here, the authors use split drives with recoded rescue elements to target essential genes and minimize the appearance of NHEJ alleles while also leaving no trace of Cas9.
format	article
author	Gerard Terradas Anna B. Buchman Jared B. Bennett Isaiah Shriner John M. Marshall Omar S. Akbari Ethan Bier
author_facet	Gerard Terradas Anna B. Buchman Jared B. Bennett Isaiah Shriner John M. Marshall Omar S. Akbari Ethan Bier
author_sort	Gerard Terradas
title	Inherently confinable split-drive systems in Drosophila
title_short	Inherently confinable split-drive systems in Drosophila
title_full	Inherently confinable split-drive systems in Drosophila
title_fullStr	Inherently confinable split-drive systems in Drosophila
title_full_unstemmed	Inherently confinable split-drive systems in Drosophila
title_sort	inherently confinable split-drive systems in drosophila
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f6bec46693bd4699adc26f312c9e760c
work_keys_str_mv	AT gerardterradas inherentlyconfinablesplitdrivesystemsindrosophila AT annabbuchman inherentlyconfinablesplitdrivesystemsindrosophila AT jaredbbennett inherentlyconfinablesplitdrivesystemsindrosophila AT isaiahshriner inherentlyconfinablesplitdrivesystemsindrosophila AT johnmmarshall inherentlyconfinablesplitdrivesystemsindrosophila AT omarsakbari inherentlyconfinablesplitdrivesystemsindrosophila AT ethanbier inherentlyconfinablesplitdrivesystemsindrosophila
_version_	1718393425602019328

Inherently confinable split-drive systems in Drosophila

Ejemplares similares