A cross-species analysis of systemic mediators of repair and complex tissue regeneration

Abstract Regeneration is an elegant and complex process informed by both local and long-range signals. Many current studies on regeneration are largely limited to investigations of local modulators within a canonical cohort of model organisms. Enhanced genetic tools increasingly enable precise tempo...

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Autores principales:	Julia Losner, Katharine Courtemanche, Jessica L. Whited
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/f6c31968a81740f6ad9728b555614f8d
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spelling	oai:doaj.org-article:f6c31968a81740f6ad9728b555614f8d2021-12-02T14:25:02ZA cross-species analysis of systemic mediators of repair and complex tissue regeneration10.1038/s41536-021-00130-62057-3995https://doaj.org/article/f6c31968a81740f6ad9728b555614f8d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00130-6https://doaj.org/toc/2057-3995Abstract Regeneration is an elegant and complex process informed by both local and long-range signals. Many current studies on regeneration are largely limited to investigations of local modulators within a canonical cohort of model organisms. Enhanced genetic tools increasingly enable precise temporal and spatial perturbations within these model regenerators, and these have primarily been applied to cells within the local injury site. Meanwhile, many aspects of broader spatial regulators of regeneration have not yet been examined with the same level of scrutiny. Recent studies have shed important insight into the significant effects of environmental cues and circulating factors on the regenerative process. These observations highlight that consideration of more systemic and possibly more broadly acting cues will also be critical to fully understand complex tissue regeneration. In this review, we explore the ways in which systemic cues and circulating factors affect the initiation of regeneration, the regenerative process, and its outcome. As this is a broad topic, we conceptually divide the factors based on their initial input as either external cues (for example, starvation and light/dark cycle) or internal cues (for example, hormones); however, all of these inputs ultimately lead to internal responses. We consider studies performed in a diverse set of organisms, including vertebrates and invertebrates. Through analysis of systemic mediators of regeneration, we argue that increased investigation of these “systemic factors” could reveal novel insights that may pave the way for a diverse set of therapeutic avenues.Julia LosnerKatharine CourtemancheJessica L. WhitedNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Julia Losner Katharine Courtemanche Jessica L. Whited A cross-species analysis of systemic mediators of repair and complex tissue regeneration
description	Abstract Regeneration is an elegant and complex process informed by both local and long-range signals. Many current studies on regeneration are largely limited to investigations of local modulators within a canonical cohort of model organisms. Enhanced genetic tools increasingly enable precise temporal and spatial perturbations within these model regenerators, and these have primarily been applied to cells within the local injury site. Meanwhile, many aspects of broader spatial regulators of regeneration have not yet been examined with the same level of scrutiny. Recent studies have shed important insight into the significant effects of environmental cues and circulating factors on the regenerative process. These observations highlight that consideration of more systemic and possibly more broadly acting cues will also be critical to fully understand complex tissue regeneration. In this review, we explore the ways in which systemic cues and circulating factors affect the initiation of regeneration, the regenerative process, and its outcome. As this is a broad topic, we conceptually divide the factors based on their initial input as either external cues (for example, starvation and light/dark cycle) or internal cues (for example, hormones); however, all of these inputs ultimately lead to internal responses. We consider studies performed in a diverse set of organisms, including vertebrates and invertebrates. Through analysis of systemic mediators of regeneration, we argue that increased investigation of these “systemic factors” could reveal novel insights that may pave the way for a diverse set of therapeutic avenues.
format	article
author	Julia Losner Katharine Courtemanche Jessica L. Whited
author_facet	Julia Losner Katharine Courtemanche Jessica L. Whited
author_sort	Julia Losner
title	A cross-species analysis of systemic mediators of repair and complex tissue regeneration
title_short	A cross-species analysis of systemic mediators of repair and complex tissue regeneration
title_full	A cross-species analysis of systemic mediators of repair and complex tissue regeneration
title_fullStr	A cross-species analysis of systemic mediators of repair and complex tissue regeneration
title_full_unstemmed	A cross-species analysis of systemic mediators of repair and complex tissue regeneration
title_sort	cross-species analysis of systemic mediators of repair and complex tissue regeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f6c31968a81740f6ad9728b555614f8d
work_keys_str_mv	AT julialosner acrossspeciesanalysisofsystemicmediatorsofrepairandcomplextissueregeneration AT katharinecourtemanche acrossspeciesanalysisofsystemicmediatorsofrepairandcomplextissueregeneration AT jessicalwhited acrossspeciesanalysisofsystemicmediatorsofrepairandcomplextissueregeneration AT julialosner crossspeciesanalysisofsystemicmediatorsofrepairandcomplextissueregeneration AT katharinecourtemanche crossspeciesanalysisofsystemicmediatorsofrepairandcomplextissueregeneration AT jessicalwhited crossspeciesanalysisofsystemicmediatorsofrepairandcomplextissueregeneration
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A cross-species analysis of systemic mediators of repair and complex tissue regeneration

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