miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novoacute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML...

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Autores principales:	Xi Jiang, Chao Hu, Stephen Arnovitz, Jason Bugno, Miao Yu, Zhixiang Zuo, Ping Chen, Hao Huang, Bryan Ulrich, Sandeep Gurbuxani, Hengyou Weng, Jennifer Strong, Yungui Wang, Yuanyuan Li, Justin Salat, Shenglai Li, Abdel G. Elkahloun, Yang Yang, Mary Beth Neilly, Richard A. Larson, Michelle M. Le Beau, Tobias Herold, Stefan K. Bohlander, Paul P. Liu, Jiwang Zhang, Zejuan Li, Chuan He, Jie Jin, Seungpyo Hong, Jianjun Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6c55704ac9d48718faf67aaba2ba41b
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spelling	oai:doaj.org-article:f6c55704ac9d48718faf67aaba2ba41b2021-12-02T15:35:21ZmiR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia10.1038/ncomms114522041-1723https://doaj.org/article/f6c55704ac9d48718faf67aaba2ba41b2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11452https://doaj.org/toc/2041-1723Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novoacute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.Xi JiangChao HuStephen ArnovitzJason BugnoMiao YuZhixiang ZuoPing ChenHao HuangBryan UlrichSandeep GurbuxaniHengyou WengJennifer StrongYungui WangYuanyuan LiJustin SalatShenglai LiAbdel G. ElkahlounYang YangMary Beth NeillyRichard A. LarsonMichelle M. Le BeauTobias HeroldStefan K. BohlanderPaul P. LiuJiwang ZhangZejuan LiChuan HeJie JinSeungpyo HongJianjun ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xi Jiang Chao Hu Stephen Arnovitz Jason Bugno Miao Yu Zhixiang Zuo Ping Chen Hao Huang Bryan Ulrich Sandeep Gurbuxani Hengyou Weng Jennifer Strong Yungui Wang Yuanyuan Li Justin Salat Shenglai Li Abdel G. Elkahloun Yang Yang Mary Beth Neilly Richard A. Larson Michelle M. Le Beau Tobias Herold Stefan K. Bohlander Paul P. Liu Jiwang Zhang Zejuan Li Chuan He Jie Jin Seungpyo Hong Jianjun Chen miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
description	Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novoacute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.
format	article
author	Xi Jiang Chao Hu Stephen Arnovitz Jason Bugno Miao Yu Zhixiang Zuo Ping Chen Hao Huang Bryan Ulrich Sandeep Gurbuxani Hengyou Weng Jennifer Strong Yungui Wang Yuanyuan Li Justin Salat Shenglai Li Abdel G. Elkahloun Yang Yang Mary Beth Neilly Richard A. Larson Michelle M. Le Beau Tobias Herold Stefan K. Bohlander Paul P. Liu Jiwang Zhang Zejuan Li Chuan He Jie Jin Seungpyo Hong Jianjun Chen
author_facet	Xi Jiang Chao Hu Stephen Arnovitz Jason Bugno Miao Yu Zhixiang Zuo Ping Chen Hao Huang Bryan Ulrich Sandeep Gurbuxani Hengyou Weng Jennifer Strong Yungui Wang Yuanyuan Li Justin Salat Shenglai Li Abdel G. Elkahloun Yang Yang Mary Beth Neilly Richard A. Larson Michelle M. Le Beau Tobias Herold Stefan K. Bohlander Paul P. Liu Jiwang Zhang Zejuan Li Chuan He Jie Jin Seungpyo Hong Jianjun Chen
author_sort	Xi Jiang
title	miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
title_short	miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
title_full	miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
title_fullStr	miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
title_full_unstemmed	miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
title_sort	mir-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f6c55704ac9d48718faf67aaba2ba41b
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miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

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