Giant cell arteritis presenting as a stroke in the internal carotid artery territory: a case-based review

Giant cell arteritis (GCA) is a large-vessel vasculitis, typically affecting the aorta and its branches. The involvement of vertebral and internal carotid arteries occurs in a limited number of cases, and stroke as a presenting symptom of GCA is extremely unusual: this subset of the disease has a po...

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Autores principales:	Edoardo Conticini, Paolo Falsetti, Marco Bardelli, Luca Cantarini, Bruno Frediani
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2021
Materias:	stroke vasculitis ultrasonography giant cell arteritis. Medicine R
Acceso en línea:	https://doaj.org/article/f6c64977e6ad47a98e5885d4362e95eb
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spelling	oai:doaj.org-article:f6c64977e6ad47a98e5885d4362e95eb2021-12-02T17:18:53ZGiant cell arteritis presenting as a stroke in the internal carotid artery territory: a case-based review0034-62332084-983410.5114/reum.2021.105414https://doaj.org/article/f6c64977e6ad47a98e5885d4362e95eb2021-04-01T00:00:00Zhttps://www.termedia.pl/Giant-cell-arteritis-presenting-as-a-stroke-in-the-internal-carotid-artery-territory-a-case-based-review,18,43870,1,1.htmlhttps://doaj.org/toc/0034-6233https://doaj.org/toc/2084-9834Giant cell arteritis (GCA) is a large-vessel vasculitis, typically affecting the aorta and its branches. The involvement of vertebral and internal carotid arteries occurs in a limited number of cases, and stroke as a presenting symptom of GCA is extremely unusual: this subset of the disease has a poor prognosis and rarely responds to immunosuppression. We report the case of a 70-year-old woman, who presented to the Emergency Department for ischemic stroke, which appeared to be the first and only symptom of GCA. The prompt administration of steroids and tocilizumab (TCZ) led to clinical and radiological resolution, with no residual disability at 6-month follow-up. Our case-based review, highlighting the rarity of a large vessel vasculitis presenting only with a cerebrovascular accident, provides new evidence for the efficacy of TCZ even in more unusual varieties of GCA: in these cases, TCZ should be immediately prescribed, in order to prevent mortality and severe long-term morbidity.Edoardo ConticiniPaolo FalsettiMarco BardelliLuca CantariniBruno FredianiTermedia Publishing Housearticlestroke vasculitis ultrasonography giant cell arteritis.MedicineRENRheumatology, Vol 59, Iss 2, Pp 121-125 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke vasculitis ultrasonography giant cell arteritis. Medicine R
spellingShingle	stroke vasculitis ultrasonography giant cell arteritis. Medicine R Edoardo Conticini Paolo Falsetti Marco Bardelli Luca Cantarini Bruno Frediani Giant cell arteritis presenting as a stroke in the internal carotid artery territory: a case-based review
description	Giant cell arteritis (GCA) is a large-vessel vasculitis, typically affecting the aorta and its branches. The involvement of vertebral and internal carotid arteries occurs in a limited number of cases, and stroke as a presenting symptom of GCA is extremely unusual: this subset of the disease has a poor prognosis and rarely responds to immunosuppression. We report the case of a 70-year-old woman, who presented to the Emergency Department for ischemic stroke, which appeared to be the first and only symptom of GCA. The prompt administration of steroids and tocilizumab (TCZ) led to clinical and radiological resolution, with no residual disability at 6-month follow-up. Our case-based review, highlighting the rarity of a large vessel vasculitis presenting only with a cerebrovascular accident, provides new evidence for the efficacy of TCZ even in more unusual varieties of GCA: in these cases, TCZ should be immediately prescribed, in order to prevent mortality and severe long-term morbidity.
format	article
author	Edoardo Conticini Paolo Falsetti Marco Bardelli Luca Cantarini Bruno Frediani
author_facet	Edoardo Conticini Paolo Falsetti Marco Bardelli Luca Cantarini Bruno Frediani
author_sort	Edoardo Conticini
title	Giant cell arteritis presenting as a stroke in the internal carotid artery territory: a case-based review
title_short	Giant cell arteritis presenting as a stroke in the internal carotid artery territory: a case-based review
title_full	Giant cell arteritis presenting as a stroke in the internal carotid artery territory: a case-based review
title_fullStr	Giant cell arteritis presenting as a stroke in the internal carotid artery territory: a case-based review
title_full_unstemmed	Giant cell arteritis presenting as a stroke in the internal carotid artery territory: a case-based review
title_sort	giant cell arteritis presenting as a stroke in the internal carotid artery territory: a case-based review
publisher	Termedia Publishing House
publishDate	2021
url	https://doaj.org/article/f6c64977e6ad47a98e5885d4362e95eb
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Giant cell arteritis presenting as a stroke in the internal carotid artery territory: a case-based review

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