Coronavirus disease 2019 (COVID-19): NETosis-associated mechanisms of progression and prospects for therapy regulating the formation of neutrophil extracellular traps (NETs)

Infectious disease COVID-19 caused by the SARS-CoV-2 coronavirus is characterized by high contagiousness, complexity of pathogenesis and unpredictability of the clinical course. In severe cases, which are especially susceptible to men, the elderly and people with underlying medical conditions such a...

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Autores principales:	K. A. Aitbaev, I. T. Murkamilov, V. V. Fomin, I. O. Kudaibergenova, F. A. Yusupov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	covid-19 sars-cov-2 net neutrophils Science Q
Acceso en línea:	https://doaj.org/article/f6c9b1f35696463ba459eaf4832d0e49
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spelling	oai:doaj.org-article:f6c9b1f35696463ba459eaf4832d0e492021-11-23T06:14:46ZCoronavirus disease 2019 (COVID-19): NETosis-associated mechanisms of progression and prospects for therapy regulating the formation of neutrophil extracellular traps (NETs)2541-94202587-959610.29413/ABS.2021-6.4.6https://doaj.org/article/f6c9b1f35696463ba459eaf4832d0e492021-10-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2974https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Infectious disease COVID-19 caused by the SARS-CoV-2 coronavirus is characterized by high contagiousness, complexity of pathogenesis and unpredictability of the clinical course. In severe cases, which are especially susceptible to men, the elderly and people with underlying medical conditions such as obesity, diabetes, hypertension, cardiovascular and chronic respiratory diseases, the infection leads to respiratory failure and death due to the development of an extensive inflammatory reaction. As a result of many studies, it has been established that one of the leading causes of the severe course and death of patients with COVID-19 is the development of coagulopathy, that is, increased thrombus formation in small vessels due to excessive activity of neutrophils, which form the so-called neutrophil extracellular traps (NETs). Although NETs play a useful role in protecting their host from pathogens, their overgrowth can trigger a cascade of adverse reactions including: the production of antibodies against the host’s DNA (autoimmunization); damage to surrounding tissue; or the occurrence of thromboembolic complications. Therefore, extracellular neutrophil traps and their markers have been identified as targets for new therapeutic strategies aimed at reducing the severity of COVID-19 disease and/or mortality. This article describes the structure of NETs, as well as analyzes the molecular mechanisms that contribute to their overgeneration. In addition, the prospects for COVID-19 therapy aimed at regulating the formation of extracellular traps by creating drugs both limiting the production of NET structures and dissolving their excess amounts in the body of patients are discussed.K. A. AitbaevI. T. MurkamilovV. V. FominI. O. KudaibergenovaF. A. YusupovScientific Сentre for Family Health and Human Reproduction Problemsarticlecovid-19sars-cov-2netneutrophilsScienceQRUActa Biomedica Scientifica, Vol 6, Iss 4, Pp 64-73 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	covid-19 sars-cov-2 net neutrophils Science Q
spellingShingle	covid-19 sars-cov-2 net neutrophils Science Q K. A. Aitbaev I. T. Murkamilov V. V. Fomin I. O. Kudaibergenova F. A. Yusupov Coronavirus disease 2019 (COVID-19): NETosis-associated mechanisms of progression and prospects for therapy regulating the formation of neutrophil extracellular traps (NETs)
description	Infectious disease COVID-19 caused by the SARS-CoV-2 coronavirus is characterized by high contagiousness, complexity of pathogenesis and unpredictability of the clinical course. In severe cases, which are especially susceptible to men, the elderly and people with underlying medical conditions such as obesity, diabetes, hypertension, cardiovascular and chronic respiratory diseases, the infection leads to respiratory failure and death due to the development of an extensive inflammatory reaction. As a result of many studies, it has been established that one of the leading causes of the severe course and death of patients with COVID-19 is the development of coagulopathy, that is, increased thrombus formation in small vessels due to excessive activity of neutrophils, which form the so-called neutrophil extracellular traps (NETs). Although NETs play a useful role in protecting their host from pathogens, their overgrowth can trigger a cascade of adverse reactions including: the production of antibodies against the host’s DNA (autoimmunization); damage to surrounding tissue; or the occurrence of thromboembolic complications. Therefore, extracellular neutrophil traps and their markers have been identified as targets for new therapeutic strategies aimed at reducing the severity of COVID-19 disease and/or mortality. This article describes the structure of NETs, as well as analyzes the molecular mechanisms that contribute to their overgeneration. In addition, the prospects for COVID-19 therapy aimed at regulating the formation of extracellular traps by creating drugs both limiting the production of NET structures and dissolving their excess amounts in the body of patients are discussed.
format	article
author	K. A. Aitbaev I. T. Murkamilov V. V. Fomin I. O. Kudaibergenova F. A. Yusupov
author_facet	K. A. Aitbaev I. T. Murkamilov V. V. Fomin I. O. Kudaibergenova F. A. Yusupov
author_sort	K. A. Aitbaev
title	Coronavirus disease 2019 (COVID-19): NETosis-associated mechanisms of progression and prospects for therapy regulating the formation of neutrophil extracellular traps (NETs)
title_short	Coronavirus disease 2019 (COVID-19): NETosis-associated mechanisms of progression and prospects for therapy regulating the formation of neutrophil extracellular traps (NETs)
title_full	Coronavirus disease 2019 (COVID-19): NETosis-associated mechanisms of progression and prospects for therapy regulating the formation of neutrophil extracellular traps (NETs)
title_fullStr	Coronavirus disease 2019 (COVID-19): NETosis-associated mechanisms of progression and prospects for therapy regulating the formation of neutrophil extracellular traps (NETs)
title_full_unstemmed	Coronavirus disease 2019 (COVID-19): NETosis-associated mechanisms of progression and prospects for therapy regulating the formation of neutrophil extracellular traps (NETs)
title_sort	coronavirus disease 2019 (covid-19): netosis-associated mechanisms of progression and prospects for therapy regulating the formation of neutrophil extracellular traps (nets)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/f6c9b1f35696463ba459eaf4832d0e49
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Coronavirus disease 2019 (COVID-19): NETosis-associated mechanisms of progression and prospects for therapy regulating the formation of neutrophil extracellular traps (NETs)

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