Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks.

<h4>Background</h4>The neurons and synapses work coordinately to program the brain codes of controlling cognition and behaviors. Spike patterns at the presynaptic neurons regulate synaptic transmission. The quantitative regulations of synapse dynamics in spike encoding at the postsynapti...

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Autores principales:	Jiandong Yu, Hao Qian, Na Chen, Jin-Hui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6cc3efb1ee044d3ab0c5010031bbc45
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spelling	oai:doaj.org-article:f6cc3efb1ee044d3ab0c5010031bbc452021-11-04T06:08:10ZQuantal glutamate release is essential for reliable neuronal encodings in cerebral networks.1932-620310.1371/journal.pone.0025219https://doaj.org/article/f6cc3efb1ee044d3ab0c5010031bbc452011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21949885/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The neurons and synapses work coordinately to program the brain codes of controlling cognition and behaviors. Spike patterns at the presynaptic neurons regulate synaptic transmission. The quantitative regulations of synapse dynamics in spike encoding at the postsynaptic neurons remain unclear.<h4>Methodology/principal findings</h4>With dual whole-cell recordings at synapse-paired cells in mouse cortical slices, we have investigated the regulation of synapse dynamics to neuronal spike encoding at cerebral circuits assembled by pyramidal neurons and GABAergic ones. Our studies at unitary synapses show that postsynaptic responses are constant over time, such as glutamate receptor-channel currents at GABAergic neurons and glutamate transport currents at astrocytes, indicating quantal glutamate release. In terms of its physiological impact, our results demonstrate that the signals integrated from quantal glutamatergic synapses drive spike encoding at GABAergic neurons reliably, which in turn precisely set spike encoding at pyramidal neurons through feedback inhibition.<h4>Conclusion/significance</h4>Our studies provide the evidences for the quantal glutamate release to drive the spike encodings precisely in cortical circuits, which may be essential for programming the reliable codes in the brain to manage well-organized behaviors.Jiandong YuHao QianNa ChenJin-Hui WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e25219 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiandong Yu Hao Qian Na Chen Jin-Hui Wang Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks.
description	<h4>Background</h4>The neurons and synapses work coordinately to program the brain codes of controlling cognition and behaviors. Spike patterns at the presynaptic neurons regulate synaptic transmission. The quantitative regulations of synapse dynamics in spike encoding at the postsynaptic neurons remain unclear.<h4>Methodology/principal findings</h4>With dual whole-cell recordings at synapse-paired cells in mouse cortical slices, we have investigated the regulation of synapse dynamics to neuronal spike encoding at cerebral circuits assembled by pyramidal neurons and GABAergic ones. Our studies at unitary synapses show that postsynaptic responses are constant over time, such as glutamate receptor-channel currents at GABAergic neurons and glutamate transport currents at astrocytes, indicating quantal glutamate release. In terms of its physiological impact, our results demonstrate that the signals integrated from quantal glutamatergic synapses drive spike encoding at GABAergic neurons reliably, which in turn precisely set spike encoding at pyramidal neurons through feedback inhibition.<h4>Conclusion/significance</h4>Our studies provide the evidences for the quantal glutamate release to drive the spike encodings precisely in cortical circuits, which may be essential for programming the reliable codes in the brain to manage well-organized behaviors.
format	article
author	Jiandong Yu Hao Qian Na Chen Jin-Hui Wang
author_facet	Jiandong Yu Hao Qian Na Chen Jin-Hui Wang
author_sort	Jiandong Yu
title	Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks.
title_short	Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks.
title_full	Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks.
title_fullStr	Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks.
title_full_unstemmed	Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks.
title_sort	quantal glutamate release is essential for reliable neuronal encodings in cerebral networks.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/f6cc3efb1ee044d3ab0c5010031bbc45
work_keys_str_mv	AT jiandongyu quantalglutamatereleaseisessentialforreliableneuronalencodingsincerebralnetworks AT haoqian quantalglutamatereleaseisessentialforreliableneuronalencodingsincerebralnetworks AT nachen quantalglutamatereleaseisessentialforreliableneuronalencodingsincerebralnetworks AT jinhuiwang quantalglutamatereleaseisessentialforreliableneuronalencodingsincerebralnetworks
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Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks.

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