Prospects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer

Over the past decades, a large amount of data has been accumulated in various subfields of glycobiology. However, much clinically relevant data and many tools are still not widely used in medicine. Synthetic glycoconjugates with the known structure of glycans are an accurate tool for the study of gl...

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Autor principal:	Eugeniy P. Smorodin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	glycoconjugates antibodies cancer survival prognosis tumour microbiota Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f6cfc87c02dd47e2b07ae2b1172d1dd3
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spelling	oai:doaj.org-article:f6cfc87c02dd47e2b07ae2b1172d1dd32021-11-11T17:05:07ZProspects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer10.3390/ijms2221116081422-00671661-6596https://doaj.org/article/f6cfc87c02dd47e2b07ae2b1172d1dd32021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11608https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Over the past decades, a large amount of data has been accumulated in various subfields of glycobiology. However, much clinically relevant data and many tools are still not widely used in medicine. Synthetic glycoconjugates with the known structure of glycans are an accurate tool for the study of glycan-binding proteins. We used polyacrylamide glycoconjugates (PGs) including PGs with tumour-associated glycans (TAGs) in immunoassays to assess the prognostic potential of the serum level of anti-glycan antibodies (AG Abs) in gastrointestinal cancer patients and found an association of AG Abs with survival. The specificity of affinity-isolated AG Abs was investigated using synthetic and natural glycoconjugates. AG Abs showed mainly a low specificity to tumour-associated and tumour-derived mucins; therefore, the protective role of the examined circulating AG Abs against cancer remains a challenge. In this review, our findings are analysed and discussed in the context of the contribution of bacteria to the AG Abs stimulus and cancer progression. Examples of the influence of pathogenic bacteria colonising tumours on cancer progression and patient survival through mechanisms of interaction with tumours and dysregulated immune response are considered. The possibilities and problems of the integrative study of AG Abs and the microbiome using high-performance technologies are discussed.Eugeniy P. SmorodinMDPI AGarticleglycoconjugatesantibodiescancersurvivalprognosistumour microbiotaBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11608, p 11608 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glycoconjugates antibodies cancer survival prognosis tumour microbiota Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	glycoconjugates antibodies cancer survival prognosis tumour microbiota Biology (General) QH301-705.5 Chemistry QD1-999 Eugeniy P. Smorodin Prospects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer
description	Over the past decades, a large amount of data has been accumulated in various subfields of glycobiology. However, much clinically relevant data and many tools are still not widely used in medicine. Synthetic glycoconjugates with the known structure of glycans are an accurate tool for the study of glycan-binding proteins. We used polyacrylamide glycoconjugates (PGs) including PGs with tumour-associated glycans (TAGs) in immunoassays to assess the prognostic potential of the serum level of anti-glycan antibodies (AG Abs) in gastrointestinal cancer patients and found an association of AG Abs with survival. The specificity of affinity-isolated AG Abs was investigated using synthetic and natural glycoconjugates. AG Abs showed mainly a low specificity to tumour-associated and tumour-derived mucins; therefore, the protective role of the examined circulating AG Abs against cancer remains a challenge. In this review, our findings are analysed and discussed in the context of the contribution of bacteria to the AG Abs stimulus and cancer progression. Examples of the influence of pathogenic bacteria colonising tumours on cancer progression and patient survival through mechanisms of interaction with tumours and dysregulated immune response are considered. The possibilities and problems of the integrative study of AG Abs and the microbiome using high-performance technologies are discussed.
format	article
author	Eugeniy P. Smorodin
author_facet	Eugeniy P. Smorodin
author_sort	Eugeniy P. Smorodin
title	Prospects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer
title_short	Prospects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer
title_full	Prospects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer
title_fullStr	Prospects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer
title_full_unstemmed	Prospects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer
title_sort	prospects and challenges of the study of anti-glycan antibodies and microbiota for the monitoring of gastrointestinal cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f6cfc87c02dd47e2b07ae2b1172d1dd3
work_keys_str_mv	AT eugeniypsmorodin prospectsandchallengesofthestudyofantiglycanantibodiesandmicrobiotaforthemonitoringofgastrointestinalcancer
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Prospects and Challenges of the Study of Anti-Glycan Antibodies and Microbiota for the Monitoring of Gastrointestinal Cancer

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