Erythrocytes 3D genome organization in vertebrates

Abstract Generation of mature red blood cells, consisting mainly of hemoglobin, is a remarkable example of coordinated action of various signaling networks. Chromatin condensation is an essential step for terminal erythroid differentiation and subsequent nuclear expulsion in mammals. Here, we profil...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anastasia Ryzhkova, Alena Taskina, Anna Khabarova, Veniamin Fishman, Nariman Battulin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6d46493b1d64375aa60fcf3b26b5b2c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f6d46493b1d64375aa60fcf3b26b5b2c
record_format	dspace
spelling	oai:doaj.org-article:f6d46493b1d64375aa60fcf3b26b5b2c2021-12-02T13:34:46ZErythrocytes 3D genome organization in vertebrates10.1038/s41598-021-83903-92045-2322https://doaj.org/article/f6d46493b1d64375aa60fcf3b26b5b2c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83903-9https://doaj.org/toc/2045-2322Abstract Generation of mature red blood cells, consisting mainly of hemoglobin, is a remarkable example of coordinated action of various signaling networks. Chromatin condensation is an essential step for terminal erythroid differentiation and subsequent nuclear expulsion in mammals. Here, we profiled 3D genome organization in the blood cells from ten species belonging to different vertebrate classes. Our analysis of contact maps revealed a striking absence of such 3D interaction patterns as loops or TADs in blood cells of all analyzed representatives. We also detect large-scale chromatin rearrangements in blood cells from mammals, birds, reptiles and amphibians: their contact maps display strong second diagonal pattern, representing an increased frequency of long-range contacts, unrelated to TADs or compartments. This pattern is completely atypical for interphase chromosome structure. We confirm that these principles of genome organization are conservative in vertebrate erythroid cells.Anastasia RyzhkovaAlena TaskinaAnna KhabarovaVeniamin FishmanNariman BattulinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anastasia Ryzhkova Alena Taskina Anna Khabarova Veniamin Fishman Nariman Battulin Erythrocytes 3D genome organization in vertebrates
description	Abstract Generation of mature red blood cells, consisting mainly of hemoglobin, is a remarkable example of coordinated action of various signaling networks. Chromatin condensation is an essential step for terminal erythroid differentiation and subsequent nuclear expulsion in mammals. Here, we profiled 3D genome organization in the blood cells from ten species belonging to different vertebrate classes. Our analysis of contact maps revealed a striking absence of such 3D interaction patterns as loops or TADs in blood cells of all analyzed representatives. We also detect large-scale chromatin rearrangements in blood cells from mammals, birds, reptiles and amphibians: their contact maps display strong second diagonal pattern, representing an increased frequency of long-range contacts, unrelated to TADs or compartments. This pattern is completely atypical for interphase chromosome structure. We confirm that these principles of genome organization are conservative in vertebrate erythroid cells.
format	article
author	Anastasia Ryzhkova Alena Taskina Anna Khabarova Veniamin Fishman Nariman Battulin
author_facet	Anastasia Ryzhkova Alena Taskina Anna Khabarova Veniamin Fishman Nariman Battulin
author_sort	Anastasia Ryzhkova
title	Erythrocytes 3D genome organization in vertebrates
title_short	Erythrocytes 3D genome organization in vertebrates
title_full	Erythrocytes 3D genome organization in vertebrates
title_fullStr	Erythrocytes 3D genome organization in vertebrates
title_full_unstemmed	Erythrocytes 3D genome organization in vertebrates
title_sort	erythrocytes 3d genome organization in vertebrates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f6d46493b1d64375aa60fcf3b26b5b2c
work_keys_str_mv	AT anastasiaryzhkova erythrocytes3dgenomeorganizationinvertebrates AT alenataskina erythrocytes3dgenomeorganizationinvertebrates AT annakhabarova erythrocytes3dgenomeorganizationinvertebrates AT veniaminfishman erythrocytes3dgenomeorganizationinvertebrates AT narimanbattulin erythrocytes3dgenomeorganizationinvertebrates
_version_	1718392772217536512

Erythrocytes 3D genome organization in vertebrates

Ejemplares similares