Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening

Abstract The biological mechanisms involved in aseptic loosening include inflammation-associated and bone resorption-associated processes. Coordinated cellular actions result in biochemical imbalances with devastating consequences for the joint. Given that this condition is not known for showing sys...

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Autores principales:	Gema Vallés, Eduardo García-Rey, Laura Saldaña, Eduardo García-Cimbrelo, Nuria Vilaboa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6d712953212402db4e158256b05b981
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spelling	oai:doaj.org-article:f6d712953212402db4e158256b05b9812021-12-02T15:23:08ZWear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening10.1038/s41598-020-79813-x2045-2322https://doaj.org/article/f6d712953212402db4e158256b05b9812021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79813-xhttps://doaj.org/toc/2045-2322Abstract The biological mechanisms involved in aseptic loosening include inflammation-associated and bone resorption-associated processes. Coordinated cellular actions result in biochemical imbalances with devastating consequences for the joint. Given that this condition is not known for showing systemic signs, we investigated whether circulating levels of inflammation-related proteins are altered in patients with aseptic loosening. Our study included 37 patients who underwent revision surgery due to hip osteolysis and aseptic loosening and 31 patients who underwent primary total hip arthroplasty. Using antibody arrays, we evaluated the serum levels of 320 proteins in four patients from each group. The results showed differences in insulin-like growth factor-binding protein 1 (IGFBP-1) concentrations, which we then quantified using enzyme-linked immunosorbent assay tests in all study patients. The results confirmed that serum IGFBP-1 concentrations were higher in the revision surgery patients than in the hip arthroplasty patients. In vitro studies showed that exposure of human osteoblasts to titanium particles induced an IGFBP-1 release that further increased when exposure to particles was performed in media conditioned by human M1 macrophages. These findings suggest that elevated serum IGFBP-1 levels in patients with aseptic loosening can arise from increased local IGFBP-1 production in the inflammatory environment of the periprosthetic bed.Gema VallésEduardo García-ReyLaura SaldañaEduardo García-CimbreloNuria VilaboaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gema Vallés Eduardo García-Rey Laura Saldaña Eduardo García-Cimbrelo Nuria Vilaboa Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening
description	Abstract The biological mechanisms involved in aseptic loosening include inflammation-associated and bone resorption-associated processes. Coordinated cellular actions result in biochemical imbalances with devastating consequences for the joint. Given that this condition is not known for showing systemic signs, we investigated whether circulating levels of inflammation-related proteins are altered in patients with aseptic loosening. Our study included 37 patients who underwent revision surgery due to hip osteolysis and aseptic loosening and 31 patients who underwent primary total hip arthroplasty. Using antibody arrays, we evaluated the serum levels of 320 proteins in four patients from each group. The results showed differences in insulin-like growth factor-binding protein 1 (IGFBP-1) concentrations, which we then quantified using enzyme-linked immunosorbent assay tests in all study patients. The results confirmed that serum IGFBP-1 concentrations were higher in the revision surgery patients than in the hip arthroplasty patients. In vitro studies showed that exposure of human osteoblasts to titanium particles induced an IGFBP-1 release that further increased when exposure to particles was performed in media conditioned by human M1 macrophages. These findings suggest that elevated serum IGFBP-1 levels in patients with aseptic loosening can arise from increased local IGFBP-1 production in the inflammatory environment of the periprosthetic bed.
format	article
author	Gema Vallés Eduardo García-Rey Laura Saldaña Eduardo García-Cimbrelo Nuria Vilaboa
author_facet	Gema Vallés Eduardo García-Rey Laura Saldaña Eduardo García-Cimbrelo Nuria Vilaboa
author_sort	Gema Vallés
title	Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening
title_short	Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening
title_full	Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening
title_fullStr	Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening
title_full_unstemmed	Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening
title_sort	wear of hip prostheses increases serum igfbp-1 levels in patients with aseptic loosening
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f6d712953212402db4e158256b05b981
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Wear of hip prostheses increases serum IGFBP-1 levels in patients with aseptic loosening

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