Blood and lymphatic systems are segregated by the FLCN tumor suppressor

Blood and lymphatic vessels bear a strong resemblance but do not share a lumen, thus maintaining their distinct functions. Here, the authors describe that Folliculin, a tumor suppressor, prevents the fusion of these vessels during development by limiting the plasticity of venous and lymphatic endoth...

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Autores principales:	Ikue Tai-Nagara, Yukiko Hasumi, Dai Kusumoto, Hisashi Hasumi, Keisuke Okabe, Tomofumi Ando, Fumio Matsuzaki, Fumiko Itoh, Hideyuki Saya, Chang Liu, Wenling Li, Yoh-suke Mukouyama, W. Marston Linehan, Xinyi Liu, Masanori Hirashima, Yutaka Suzuki, Shintaro Funasaki, Yorifumi Satou, Mitsuko Furuya, Masaya Baba, Yoshiaki Kubota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6dbc6531325464ea278f5550b28f758
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spelling	oai:doaj.org-article:f6dbc6531325464ea278f5550b28f7582021-12-02T13:57:22ZBlood and lymphatic systems are segregated by the FLCN tumor suppressor10.1038/s41467-020-20156-62041-1723https://doaj.org/article/f6dbc6531325464ea278f5550b28f7582020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20156-6https://doaj.org/toc/2041-1723Blood and lymphatic vessels bear a strong resemblance but do not share a lumen, thus maintaining their distinct functions. Here, the authors describe that Folliculin, a tumor suppressor, prevents the fusion of these vessels during development by limiting the plasticity of venous and lymphatic endothelial cells.Ikue Tai-NagaraYukiko HasumiDai KusumotoHisashi HasumiKeisuke OkabeTomofumi AndoFumio MatsuzakiFumiko ItohHideyuki SayaChang LiuWenling LiYoh-suke MukouyamaW. Marston LinehanXinyi LiuMasanori HirashimaYutaka SuzukiShintaro FunasakiYorifumi SatouMitsuko FuruyaMasaya BabaYoshiaki KubotaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ikue Tai-Nagara Yukiko Hasumi Dai Kusumoto Hisashi Hasumi Keisuke Okabe Tomofumi Ando Fumio Matsuzaki Fumiko Itoh Hideyuki Saya Chang Liu Wenling Li Yoh-suke Mukouyama W. Marston Linehan Xinyi Liu Masanori Hirashima Yutaka Suzuki Shintaro Funasaki Yorifumi Satou Mitsuko Furuya Masaya Baba Yoshiaki Kubota Blood and lymphatic systems are segregated by the FLCN tumor suppressor
description	Blood and lymphatic vessels bear a strong resemblance but do not share a lumen, thus maintaining their distinct functions. Here, the authors describe that Folliculin, a tumor suppressor, prevents the fusion of these vessels during development by limiting the plasticity of venous and lymphatic endothelial cells.
format	article
author	Ikue Tai-Nagara Yukiko Hasumi Dai Kusumoto Hisashi Hasumi Keisuke Okabe Tomofumi Ando Fumio Matsuzaki Fumiko Itoh Hideyuki Saya Chang Liu Wenling Li Yoh-suke Mukouyama W. Marston Linehan Xinyi Liu Masanori Hirashima Yutaka Suzuki Shintaro Funasaki Yorifumi Satou Mitsuko Furuya Masaya Baba Yoshiaki Kubota
author_facet	Ikue Tai-Nagara Yukiko Hasumi Dai Kusumoto Hisashi Hasumi Keisuke Okabe Tomofumi Ando Fumio Matsuzaki Fumiko Itoh Hideyuki Saya Chang Liu Wenling Li Yoh-suke Mukouyama W. Marston Linehan Xinyi Liu Masanori Hirashima Yutaka Suzuki Shintaro Funasaki Yorifumi Satou Mitsuko Furuya Masaya Baba Yoshiaki Kubota
author_sort	Ikue Tai-Nagara
title	Blood and lymphatic systems are segregated by the FLCN tumor suppressor
title_short	Blood and lymphatic systems are segregated by the FLCN tumor suppressor
title_full	Blood and lymphatic systems are segregated by the FLCN tumor suppressor
title_fullStr	Blood and lymphatic systems are segregated by the FLCN tumor suppressor
title_full_unstemmed	Blood and lymphatic systems are segregated by the FLCN tumor suppressor
title_sort	blood and lymphatic systems are segregated by the flcn tumor suppressor
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f6dbc6531325464ea278f5550b28f758
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Blood and lymphatic systems are segregated by the FLCN tumor suppressor

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