Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis

Recently there was an increase of Clostridium difficile infection cases with the development of severe pseudomembranous colitis with high mortality and high percentage of backsets. Major reason for this growing problem is the emergence of newer, more virulent and more antibiotic-resistant strains in...

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Autor principal:	E. I. Belinskaya
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2015
Materias:	pseudomembranous colitis clostridium difficile infection peritonitis Science Q
Acceso en línea:	https://doaj.org/article/f6dbff00d68e4f668f37bcfd9bed0a70
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spelling	oai:doaj.org-article:f6dbff00d68e4f668f37bcfd9bed0a702021-11-23T06:14:32ZCases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis2541-94202587-9596https://doaj.org/article/f6dbff00d68e4f668f37bcfd9bed0a702015-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/82https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Recently there was an increase of Clostridium difficile infection cases with the development of severe pseudomembranous colitis with high mortality and high percentage of backsets. Major reason for this growing problem is the emergence of newer, more virulent and more antibiotic-resistant strains including PCR ribotype 027. The major risk factors for pseudomembranous colitis are hospitalizing, antibiotics exposure, chemotherapy, use of proton-pumps inhibitors, older age, concomitant diseases. The appearance of diarrhea, acute abdominal pain, leukocytosis, hypoproteinemia after antibiotic therapy should be considered as a basis for targeted diagnostics of pseudomembranous colitis with the use of laboratory tests. Fulminant pseudomembranous colitis occurs in 5 % of patient with Clostridium difficile infection. This patients often have severe abdominal pain and can have signs of peritonitis and a markedly increased white blood cells. Colectomy should be considered in patients with fulminant colitis. The mortality rate in fulminant pseudomembranous colitis is up to 70 %. The basis for the prevention of pseudomembranous colitis is a rational prescription of antibacterial agents.E. I. BelinskayaScientific Сentre for Family Health and Human Reproduction Problemsarticlepseudomembranous colitisclostridium difficile infectionperitonitisScienceQRUActa Biomedica Scientifica, Vol 0, Iss 4, Pp 7-11 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	pseudomembranous colitis clostridium difficile infection peritonitis Science Q
spellingShingle	pseudomembranous colitis clostridium difficile infection peritonitis Science Q E. I. Belinskaya Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis
description	Recently there was an increase of Clostridium difficile infection cases with the development of severe pseudomembranous colitis with high mortality and high percentage of backsets. Major reason for this growing problem is the emergence of newer, more virulent and more antibiotic-resistant strains including PCR ribotype 027. The major risk factors for pseudomembranous colitis are hospitalizing, antibiotics exposure, chemotherapy, use of proton-pumps inhibitors, older age, concomitant diseases. The appearance of diarrhea, acute abdominal pain, leukocytosis, hypoproteinemia after antibiotic therapy should be considered as a basis for targeted diagnostics of pseudomembranous colitis with the use of laboratory tests. Fulminant pseudomembranous colitis occurs in 5 % of patient with Clostridium difficile infection. This patients often have severe abdominal pain and can have signs of peritonitis and a markedly increased white blood cells. Colectomy should be considered in patients with fulminant colitis. The mortality rate in fulminant pseudomembranous colitis is up to 70 %. The basis for the prevention of pseudomembranous colitis is a rational prescription of antibacterial agents.
format	article
author	E. I. Belinskaya
author_facet	E. I. Belinskaya
author_sort	E. I. Belinskaya
title	Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis
title_short	Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis
title_full	Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis
title_fullStr	Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis
title_full_unstemmed	Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis
title_sort	cases of severe clostridium difficile colitis proceeding with symptoms of peritonitis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2015
url	https://doaj.org/article/f6dbff00d68e4f668f37bcfd9bed0a70
work_keys_str_mv	AT eibelinskaya casesofsevereclostridiumdifficilecolitisproceedingwithsymptomsofperitonitis
_version_	1718417108947173376

Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis

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