Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study

BACKGROUND: Type 2 diabetes (T2D) is multifactorial disease. NATION epidemiological study may provide the information about the prevalence of T2D and prediabetic state in patients with different risk factor combinations in Russian population. AIMS: To evaluate the prevalence of T2D and prediabetic...

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Autores principales:	Ekaterina A. Shestakova, Elena Y. Lunina, Gagik R. Galstyan, Marina V. Shestakova, Ivan I. Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2020
Materias:	type 2 diabetes prediabetic state risk factors obesity family history age hypertension Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/f6ddda5308294ef9b371f0e108e87a02
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spelling	oai:doaj.org-article:f6ddda5308294ef9b371f0e108e87a022021-11-14T09:00:22ZType 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study2072-03512072-037810.14341/DM12286https://doaj.org/article/f6ddda5308294ef9b371f0e108e87a022020-04-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12286https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378BACKGROUND: Type 2 diabetes (T2D) is multifactorial disease. NATION epidemiological study may provide the information about the prevalence of T2D and prediabetic state in patients with different risk factor combinations in Russian population. AIMS: To evaluate the prevalence of T2D and prediabetic state in NATION cohort depending on the amount of diabetes risk factors. MATERIALS AND METHODS: NATION is an epidemiological, cross-sectional study, designed to assess the prevalence of T2D in Russian adult population, where HbA1c was used to establish T2D (HbAc≥6,5%) and prediabetes (5,7%≤HbA1c<6,5%). Patients with T2D were either previously diagnosed or newly diagnosed. Current study presents an additional analysis of NATION cohort focused on the prevalence of T2D and prediabetic state among patients with different risk factor combinations. RESULTS: T2D and prediabetic state prevalence gradually increased among patients with following risk factors (prevalence of T2D and prediabetes respectively): low physical activity (4,3%, 18,3%), rare fruit and vegetable consumption (4,8%, 18,7%), T2D family history (7,7%, 20,3%), age ≥45 years (9,5%, 31,3%), obesity grade 1 (9,6%, 30,3%), obesity grade 2 (14,6%, 37,8%), obesity grade 3 (20,1%, 39,7%), hypertension (14,7%, 38,2%), history of diabetes during pregnancy (14,1%, 24,7%). Prevalence of T2D with single and multiple risk factors was compared to the prevalence of T2D in young patients (<45 years) without additional diabetes risk factors. Age ≥45 years was associated with 7-fold increase in T2D prevalence; obesity – 8,8-fold; family history – 5,7-fold; hypertension – 10,8-fold (p<0,001 for comparisons of every group with patients <45 years of age without other risk factors). When one patient had several risk factors combined, the prevalence of T2D increased progressively: combination of age ≥45 years and family history led to 10,7-fold rise; combination of age ≥45 years and BMI≥30kg/m2 – 11,2-fold; combination of age ≥45 years, family history and BMI≥30kg/m2 – 15,3-fold; combination of age ≥45 years, family history, BMI≥30kg/m2 and hypertension – 19,1-fold (p<0,001 for comparisons of every group with patients <45 years of age without other risk factors). CONCLUSIONS: Presence of multiple risk factors, such as age ≥45 years, obesity and hypertension led to progressive increase in the prevalence of T2D and prediabetic state. These data are important to identify patients at the highest risk of T2D among Russian population.Ekaterina A. ShestakovaElena Y. LuninaGagik R. GalstyanMarina V. ShestakovaIvan I. DedovEndocrinology Research Centrearticletype 2 diabetesprediabetic staterisk factorsobesityfamily historyagehypertensionNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 23, Iss 1, Pp 4-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes prediabetic state risk factors obesity family history age hypertension Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes prediabetic state risk factors obesity family history age hypertension Nutritional diseases. Deficiency diseases RC620-627 Ekaterina A. Shestakova Elena Y. Lunina Gagik R. Galstyan Marina V. Shestakova Ivan I. Dedov Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study
description	BACKGROUND: Type 2 diabetes (T2D) is multifactorial disease. NATION epidemiological study may provide the information about the prevalence of T2D and prediabetic state in patients with different risk factor combinations in Russian population. AIMS: To evaluate the prevalence of T2D and prediabetic state in NATION cohort depending on the amount of diabetes risk factors. MATERIALS AND METHODS: NATION is an epidemiological, cross-sectional study, designed to assess the prevalence of T2D in Russian adult population, where HbA1c was used to establish T2D (HbAc≥6,5%) and prediabetes (5,7%≤HbA1c<6,5%). Patients with T2D were either previously diagnosed or newly diagnosed. Current study presents an additional analysis of NATION cohort focused on the prevalence of T2D and prediabetic state among patients with different risk factor combinations. RESULTS: T2D and prediabetic state prevalence gradually increased among patients with following risk factors (prevalence of T2D and prediabetes respectively): low physical activity (4,3%, 18,3%), rare fruit and vegetable consumption (4,8%, 18,7%), T2D family history (7,7%, 20,3%), age ≥45 years (9,5%, 31,3%), obesity grade 1 (9,6%, 30,3%), obesity grade 2 (14,6%, 37,8%), obesity grade 3 (20,1%, 39,7%), hypertension (14,7%, 38,2%), history of diabetes during pregnancy (14,1%, 24,7%). Prevalence of T2D with single and multiple risk factors was compared to the prevalence of T2D in young patients (<45 years) without additional diabetes risk factors. Age ≥45 years was associated with 7-fold increase in T2D prevalence; obesity – 8,8-fold; family history – 5,7-fold; hypertension – 10,8-fold (p<0,001 for comparisons of every group with patients <45 years of age without other risk factors). When one patient had several risk factors combined, the prevalence of T2D increased progressively: combination of age ≥45 years and family history led to 10,7-fold rise; combination of age ≥45 years and BMI≥30kg/m2 – 11,2-fold; combination of age ≥45 years, family history and BMI≥30kg/m2 – 15,3-fold; combination of age ≥45 years, family history, BMI≥30kg/m2 and hypertension – 19,1-fold (p<0,001 for comparisons of every group with patients <45 years of age without other risk factors). CONCLUSIONS: Presence of multiple risk factors, such as age ≥45 years, obesity and hypertension led to progressive increase in the prevalence of T2D and prediabetic state. These data are important to identify patients at the highest risk of T2D among Russian population.
format	article
author	Ekaterina A. Shestakova Elena Y. Lunina Gagik R. Galstyan Marina V. Shestakova Ivan I. Dedov
author_facet	Ekaterina A. Shestakova Elena Y. Lunina Gagik R. Galstyan Marina V. Shestakova Ivan I. Dedov
author_sort	Ekaterina A. Shestakova
title	Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study
title_short	Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study
title_full	Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study
title_fullStr	Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study
title_full_unstemmed	Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study
title_sort	type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the nation study
publisher	Endocrinology Research Centre
publishDate	2020
url	https://doaj.org/article/f6ddda5308294ef9b371f0e108e87a02
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Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study

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