Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway

Polo-like kinase 1 (Plk1) is a key regulator of mitosis. Here, the authors show that Plk1 activates the pentose phosphate pathway in cancer cells by directly phosphorylating glucose-6-phosphate dehydrogenase (G6PD) and that such activation is critical for cell cycle progression and cancer cell growt...

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Autores principales:	Xiaoyu Ma, Lin Wang, De Huang, Yunyan Li, Dongdong Yang, Tingting Li, Fudong Li, Linchong Sun, Haoran Wei, Kun He, Fazhi Yu, Debiao Zhao, Lan Hu, Songge Xing, Zhaoji Liu, Kui Li, Jing Guo, Zhenye Yang, Xin Pan, Ailing Li, Yunyu Shi, Junfeng Wang, Ping Gao, Huafeng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6e7092fba7f4ee08377d36b15323b24
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spelling	oai:doaj.org-article:f6e7092fba7f4ee08377d36b15323b242021-12-02T14:41:18ZPolo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway10.1038/s41467-017-01647-52041-1723https://doaj.org/article/f6e7092fba7f4ee08377d36b15323b242017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01647-5https://doaj.org/toc/2041-1723Polo-like kinase 1 (Plk1) is a key regulator of mitosis. Here, the authors show that Plk1 activates the pentose phosphate pathway in cancer cells by directly phosphorylating glucose-6-phosphate dehydrogenase (G6PD) and that such activation is critical for cell cycle progression and cancer cell growth.Xiaoyu MaLin WangDe HuangYunyan LiDongdong YangTingting LiFudong LiLinchong SunHaoran WeiKun HeFazhi YuDebiao ZhaoLan HuSongge XingZhaoji LiuKui LiJing GuoZhenye YangXin PanAiling LiYunyu ShiJunfeng WangPing GaoHuafeng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoyu Ma Lin Wang De Huang Yunyan Li Dongdong Yang Tingting Li Fudong Li Linchong Sun Haoran Wei Kun He Fazhi Yu Debiao Zhao Lan Hu Songge Xing Zhaoji Liu Kui Li Jing Guo Zhenye Yang Xin Pan Ailing Li Yunyu Shi Junfeng Wang Ping Gao Huafeng Zhang Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
description	Polo-like kinase 1 (Plk1) is a key regulator of mitosis. Here, the authors show that Plk1 activates the pentose phosphate pathway in cancer cells by directly phosphorylating glucose-6-phosphate dehydrogenase (G6PD) and that such activation is critical for cell cycle progression and cancer cell growth.
format	article
author	Xiaoyu Ma Lin Wang De Huang Yunyan Li Dongdong Yang Tingting Li Fudong Li Linchong Sun Haoran Wei Kun He Fazhi Yu Debiao Zhao Lan Hu Songge Xing Zhaoji Liu Kui Li Jing Guo Zhenye Yang Xin Pan Ailing Li Yunyu Shi Junfeng Wang Ping Gao Huafeng Zhang
author_facet	Xiaoyu Ma Lin Wang De Huang Yunyan Li Dongdong Yang Tingting Li Fudong Li Linchong Sun Haoran Wei Kun He Fazhi Yu Debiao Zhao Lan Hu Songge Xing Zhaoji Liu Kui Li Jing Guo Zhenye Yang Xin Pan Ailing Li Yunyu Shi Junfeng Wang Ping Gao Huafeng Zhang
author_sort	Xiaoyu Ma
title	Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
title_short	Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
title_full	Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
title_fullStr	Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
title_full_unstemmed	Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
title_sort	polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f6e7092fba7f4ee08377d36b15323b24
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Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway

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