Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies

Human cytomegalovirus (HCMV) can evade immune responses in latent reservoirs, which is a specific problem during transplantation. Here the authors develop a bivalent nanobody that is specific for US28, a viral receptor required by latent HCMV, and show it can partially reactivate the virus and make...

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Autores principales:	Timo W. M. De Groof, Elizabeth G. Elder, Eleanor Y. Lim, Raimond Heukers, Nick D. Bergkamp, Ian J. Groves, Mark Wills, John H. Sinclair, Martine J. Smit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6e7b525a9434aba8b55e7c5d8bcbd9e
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spelling	oai:doaj.org-article:f6e7b525a9434aba8b55e7c5d8bcbd9e2021-12-02T16:43:42ZTargeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies10.1038/s41467-021-24608-52041-1723https://doaj.org/article/f6e7b525a9434aba8b55e7c5d8bcbd9e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24608-5https://doaj.org/toc/2041-1723Human cytomegalovirus (HCMV) can evade immune responses in latent reservoirs, which is a specific problem during transplantation. Here the authors develop a bivalent nanobody that is specific for US28, a viral receptor required by latent HCMV, and show it can partially reactivate the virus and make it susceptible to killing by T cells.Timo W. M. De GroofElizabeth G. ElderEleanor Y. LimRaimond HeukersNick D. BergkampIan J. GrovesMark WillsJohn H. SinclairMartine J. SmitNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Timo W. M. De Groof Elizabeth G. Elder Eleanor Y. Lim Raimond Heukers Nick D. Bergkamp Ian J. Groves Mark Wills John H. Sinclair Martine J. Smit Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
description	Human cytomegalovirus (HCMV) can evade immune responses in latent reservoirs, which is a specific problem during transplantation. Here the authors develop a bivalent nanobody that is specific for US28, a viral receptor required by latent HCMV, and show it can partially reactivate the virus and make it susceptible to killing by T cells.
format	article
author	Timo W. M. De Groof Elizabeth G. Elder Eleanor Y. Lim Raimond Heukers Nick D. Bergkamp Ian J. Groves Mark Wills John H. Sinclair Martine J. Smit
author_facet	Timo W. M. De Groof Elizabeth G. Elder Eleanor Y. Lim Raimond Heukers Nick D. Bergkamp Ian J. Groves Mark Wills John H. Sinclair Martine J. Smit
author_sort	Timo W. M. De Groof
title	Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
title_short	Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
title_full	Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
title_fullStr	Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
title_full_unstemmed	Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
title_sort	targeting the latent human cytomegalovirus reservoir for t-cell-mediated killing with virus-specific nanobodies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f6e7b525a9434aba8b55e7c5d8bcbd9e
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Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies

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