Relationship between serum total testosterone and prostate volume in aging men

Abstract Total testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. We analyzed clinical data obtained from 416 ostens...

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Autores principales:	Bo-Wen Xia, Si-Cong Zhao, Zong-Ping Chen, Chao Chen, Tian-Shu Liu, Fan Yang, Yong Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6ecc99a7a764c898d8ff712fe4fa43c
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spelling	oai:doaj.org-article:f6ecc99a7a764c898d8ff712fe4fa43c2021-12-02T15:23:08ZRelationship between serum total testosterone and prostate volume in aging men10.1038/s41598-021-93728-12045-2322https://doaj.org/article/f6ecc99a7a764c898d8ff712fe4fa43c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93728-1https://doaj.org/toc/2045-2322Abstract Total testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. We analyzed clinical data obtained from 416 ostensibly healthy men who underwent routine health check-ups and recruited and collected data from these subjects 4 years later. We analyzed the correlation between prostate volume and relevant factors, as well as the correlation between changes in prostate volume and low testosterone over a 4-year period. Men with low testosterone had significantly larger prostate volume than those in the normal testosterone group (26.86 ± 8.75 vs. 24.06 ± 6.77 P = 0.02), and subjects with low testosterone had significantly higher levels of obesity-related factors, including waist circumference, body mass index, and insulin (all P < 0.001). After adjustment for age, testosterone level was negatively correlated with prostate volume (P = 0.004), and prostate volume and 4-year changes in prostate volume were associated with low testosterone. With increased testosterone level, prostate volume showed a significant linear decreasing trend. These findings provide evidence of the relationship between testosterone and prostate volume. Additional large studies are needed to confirm these preliminary results.Bo-Wen XiaSi-Cong ZhaoZong-Ping ChenChao ChenTian-Shu LiuFan YangYong YanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bo-Wen Xia Si-Cong Zhao Zong-Ping Chen Chao Chen Tian-Shu Liu Fan Yang Yong Yan Relationship between serum total testosterone and prostate volume in aging men
description	Abstract Total testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. We analyzed clinical data obtained from 416 ostensibly healthy men who underwent routine health check-ups and recruited and collected data from these subjects 4 years later. We analyzed the correlation between prostate volume and relevant factors, as well as the correlation between changes in prostate volume and low testosterone over a 4-year period. Men with low testosterone had significantly larger prostate volume than those in the normal testosterone group (26.86 ± 8.75 vs. 24.06 ± 6.77 P = 0.02), and subjects with low testosterone had significantly higher levels of obesity-related factors, including waist circumference, body mass index, and insulin (all P < 0.001). After adjustment for age, testosterone level was negatively correlated with prostate volume (P = 0.004), and prostate volume and 4-year changes in prostate volume were associated with low testosterone. With increased testosterone level, prostate volume showed a significant linear decreasing trend. These findings provide evidence of the relationship between testosterone and prostate volume. Additional large studies are needed to confirm these preliminary results.
format	article
author	Bo-Wen Xia Si-Cong Zhao Zong-Ping Chen Chao Chen Tian-Shu Liu Fan Yang Yong Yan
author_facet	Bo-Wen Xia Si-Cong Zhao Zong-Ping Chen Chao Chen Tian-Shu Liu Fan Yang Yong Yan
author_sort	Bo-Wen Xia
title	Relationship between serum total testosterone and prostate volume in aging men
title_short	Relationship between serum total testosterone and prostate volume in aging men
title_full	Relationship between serum total testosterone and prostate volume in aging men
title_fullStr	Relationship between serum total testosterone and prostate volume in aging men
title_full_unstemmed	Relationship between serum total testosterone and prostate volume in aging men
title_sort	relationship between serum total testosterone and prostate volume in aging men
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f6ecc99a7a764c898d8ff712fe4fa43c
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_version_	1718387363541942272

Relationship between serum total testosterone and prostate volume in aging men

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