FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME

Fifty patients with primary "dry eye" syndrome underwent examination of systemic immunity including the determination of cell populations and subsets of CD3+, CD4+, CD8+, CD16+, CD20+ lymphocytes; measurements of major immunoglobulins: IgA, IgM, IgG; circulatory immune complexes (CIC); rhe...

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Autores principales:	N. N. Ratkina, O. F. Lykova, O. Y. Baturina, O. A. Klitsenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	primary “dry eye” syndrome immunologic indices classification Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f6ee1c1247d242cab2093587203a52df
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spelling	oai:doaj.org-article:f6ee1c1247d242cab2093587203a52df2021-11-18T08:03:41ZFEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME1563-06252313-741X10.15789/1563-0625-2010-6-547-552https://doaj.org/article/f6ee1c1247d242cab2093587203a52df2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/470https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XFifty patients with primary "dry eye" syndrome underwent examination of systemic immunity including the determination of cell populations and subsets of CD3+, CD4+, CD8+, CD16+, CD20+ lymphocytes; measurements of major immunoglobulins: IgA, IgM, IgG; circulatory immune complexes (CIC); rheumatoid factor, antibodies to denatured and nondenatured DNA, and phagocytic index. When compared to relatively healthy subjects (n = 30), the patients, showed decreased contents of CD3+ and CD4+T-lymphocytes, increased IgM and CIC concentrations, along with presence of autoantibodies in blood. Moreover, some variable changes were revealed in the quantities of CD8+ cytotoxic T-lymphocytes, and the values of immunoregulatory index (IRI). As based on immunologic findings, with regard of CIC contents, autoantibody titers and IRI values, we have discerned four types of primary "dry eye" syndrome, i.e., simple, cytotoxic, CIC-positive, and Sjogren's syndrome. The changes of systemic immunity in the patients with different etiology of primary "dry eye" syndrome should be considered when elaborating therapeutic strategies and aiming for prophylaxis of immunologic disorders in such a cohort of patients.N. N. RatkinaO. F. LykovaO. Y. BaturinaO. A. KlitsenkoSPb RAACIarticleprimary “dry eye” syndromeimmunologic indicesclassificationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 6, Pp 547-552 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	primary “dry eye” syndrome immunologic indices classification Immunologic diseases. Allergy RC581-607
spellingShingle	primary “dry eye” syndrome immunologic indices classification Immunologic diseases. Allergy RC581-607 N. N. Ratkina O. F. Lykova O. Y. Baturina O. A. Klitsenko FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME
description	Fifty patients with primary "dry eye" syndrome underwent examination of systemic immunity including the determination of cell populations and subsets of CD3+, CD4+, CD8+, CD16+, CD20+ lymphocytes; measurements of major immunoglobulins: IgA, IgM, IgG; circulatory immune complexes (CIC); rheumatoid factor, antibodies to denatured and nondenatured DNA, and phagocytic index. When compared to relatively healthy subjects (n = 30), the patients, showed decreased contents of CD3+ and CD4+T-lymphocytes, increased IgM and CIC concentrations, along with presence of autoantibodies in blood. Moreover, some variable changes were revealed in the quantities of CD8+ cytotoxic T-lymphocytes, and the values of immunoregulatory index (IRI). As based on immunologic findings, with regard of CIC contents, autoantibody titers and IRI values, we have discerned four types of primary "dry eye" syndrome, i.e., simple, cytotoxic, CIC-positive, and Sjogren's syndrome. The changes of systemic immunity in the patients with different etiology of primary "dry eye" syndrome should be considered when elaborating therapeutic strategies and aiming for prophylaxis of immunologic disorders in such a cohort of patients.
format	article
author	N. N. Ratkina O. F. Lykova O. Y. Baturina O. A. Klitsenko
author_facet	N. N. Ratkina O. F. Lykova O. Y. Baturina O. A. Klitsenko
author_sort	N. N. Ratkina
title	FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME
title_short	FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME
title_full	FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME
title_fullStr	FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME
title_full_unstemmed	FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME
title_sort	features of systemic immunity in patients with a primary “dry eye” syndrome
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/f6ee1c1247d242cab2093587203a52df
work_keys_str_mv	AT nnratkina featuresofsystemicimmunityinpatientswithaprimarydryeyesyndrome AT oflykova featuresofsystemicimmunityinpatientswithaprimarydryeyesyndrome AT oybaturina featuresofsystemicimmunityinpatientswithaprimarydryeyesyndrome AT oaklitsenko featuresofsystemicimmunityinpatientswithaprimarydryeyesyndrome
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FEATURES OF SYSTEMIC IMMUNITY IN PATIENTS WITH A PRIMARY “DRY EYE” SYNDROME

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