An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR

L-2-hydroxyglutarate (L-2-HG) is an important metabolite but its regulation is poorly understood. Here the authors report an L-2-HG FRET biosensor based on the allosteric transcription factor, LhgR, to monitor L-2-HG in cells and biological samples.

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Autores principales:	Zhaoqi Kang, Manman Zhang, Kaiyu Gao, Wen Zhang, Wensi Meng, Yidong Liu, Dan Xiao, Shiting Guo, Cuiqing Ma, Chao Gao, Ping Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6f1f3484bad43509543b1abe04c2573
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spelling	oai:doaj.org-article:f6f1f3484bad43509543b1abe04c25732021-12-02T17:40:27ZAn l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR10.1038/s41467-021-23723-72041-1723https://doaj.org/article/f6f1f3484bad43509543b1abe04c25732021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23723-7https://doaj.org/toc/2041-1723L-2-hydroxyglutarate (L-2-HG) is an important metabolite but its regulation is poorly understood. Here the authors report an L-2-HG FRET biosensor based on the allosteric transcription factor, LhgR, to monitor L-2-HG in cells and biological samples.Zhaoqi KangManman ZhangKaiyu GaoWen ZhangWensi MengYidong LiuDan XiaoShiting GuoCuiqing MaChao GaoPing XuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhaoqi Kang Manman Zhang Kaiyu Gao Wen Zhang Wensi Meng Yidong Liu Dan Xiao Shiting Guo Cuiqing Ma Chao Gao Ping Xu An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR
description	L-2-hydroxyglutarate (L-2-HG) is an important metabolite but its regulation is poorly understood. Here the authors report an L-2-HG FRET biosensor based on the allosteric transcription factor, LhgR, to monitor L-2-HG in cells and biological samples.
format	article
author	Zhaoqi Kang Manman Zhang Kaiyu Gao Wen Zhang Wensi Meng Yidong Liu Dan Xiao Shiting Guo Cuiqing Ma Chao Gao Ping Xu
author_facet	Zhaoqi Kang Manman Zhang Kaiyu Gao Wen Zhang Wensi Meng Yidong Liu Dan Xiao Shiting Guo Cuiqing Ma Chao Gao Ping Xu
author_sort	Zhaoqi Kang
title	An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR
title_short	An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR
title_full	An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR
title_fullStr	An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR
title_full_unstemmed	An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR
title_sort	l-2-hydroxyglutarate biosensor based on specific transcriptional regulator lhgr
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f6f1f3484bad43509543b1abe04c2573
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An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR

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