An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR

An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR

L-2-hydroxyglutarate (L-2-HG) is an important metabolite but its regulation is poorly understood. Here the authors report an L-2-HG FRET biosensor based on the allosteric transcription factor, LhgR, to monitor L-2-HG in cells and biological samples.

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Detalles Bibliográficos
Autores principales: Zhaoqi Kang, Manman Zhang, Kaiyu Gao, Wen Zhang, Wensi Meng, Yidong Liu, Dan Xiao, Shiting Guo, Cuiqing Ma, Chao Gao, Ping Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/f6f1f3484bad43509543b1abe04c2573
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