Ultraviolet radiation drives mutations in a subset of mucosal melanomas

Mucosal melanomas are not thought to be UV radiation (UVR)-driven, yet some present UVR-related mutations. Here the authors show that some mucosal melanomas, especially conjunctival, present mutations characteristic of UVR exposure, yet share structural variants typical of other mucosal melanomas.

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Autores principales:	Piyushkumar A. Mundra, Nathalie Dhomen, Manuel Rodrigues, Lauge Hjorth Mikkelsen, Nathalie Cassoux, Kelly Brooks, Sara Valpione, Jorge S. Reis-Filho, Steffen Heegaard, Marc-Henri Stern, Sergio Roman-Roman, Richard Marais
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6fb21383af743c491f2b948dc8a807b
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spelling	oai:doaj.org-article:f6fb21383af743c491f2b948dc8a807b2021-12-02T15:22:48ZUltraviolet radiation drives mutations in a subset of mucosal melanomas10.1038/s41467-020-20432-52041-1723https://doaj.org/article/f6fb21383af743c491f2b948dc8a807b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20432-5https://doaj.org/toc/2041-1723Mucosal melanomas are not thought to be UV radiation (UVR)-driven, yet some present UVR-related mutations. Here the authors show that some mucosal melanomas, especially conjunctival, present mutations characteristic of UVR exposure, yet share structural variants typical of other mucosal melanomas.Piyushkumar A. MundraNathalie DhomenManuel RodriguesLauge Hjorth MikkelsenNathalie CassouxKelly BrooksSara ValpioneJorge S. Reis-FilhoSteffen HeegaardMarc-Henri SternSergio Roman-RomanRichard MaraisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Piyushkumar A. Mundra Nathalie Dhomen Manuel Rodrigues Lauge Hjorth Mikkelsen Nathalie Cassoux Kelly Brooks Sara Valpione Jorge S. Reis-Filho Steffen Heegaard Marc-Henri Stern Sergio Roman-Roman Richard Marais Ultraviolet radiation drives mutations in a subset of mucosal melanomas
description	Mucosal melanomas are not thought to be UV radiation (UVR)-driven, yet some present UVR-related mutations. Here the authors show that some mucosal melanomas, especially conjunctival, present mutations characteristic of UVR exposure, yet share structural variants typical of other mucosal melanomas.
format	article
author	Piyushkumar A. Mundra Nathalie Dhomen Manuel Rodrigues Lauge Hjorth Mikkelsen Nathalie Cassoux Kelly Brooks Sara Valpione Jorge S. Reis-Filho Steffen Heegaard Marc-Henri Stern Sergio Roman-Roman Richard Marais
author_facet	Piyushkumar A. Mundra Nathalie Dhomen Manuel Rodrigues Lauge Hjorth Mikkelsen Nathalie Cassoux Kelly Brooks Sara Valpione Jorge S. Reis-Filho Steffen Heegaard Marc-Henri Stern Sergio Roman-Roman Richard Marais
author_sort	Piyushkumar A. Mundra
title	Ultraviolet radiation drives mutations in a subset of mucosal melanomas
title_short	Ultraviolet radiation drives mutations in a subset of mucosal melanomas
title_full	Ultraviolet radiation drives mutations in a subset of mucosal melanomas
title_fullStr	Ultraviolet radiation drives mutations in a subset of mucosal melanomas
title_full_unstemmed	Ultraviolet radiation drives mutations in a subset of mucosal melanomas
title_sort	ultraviolet radiation drives mutations in a subset of mucosal melanomas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f6fb21383af743c491f2b948dc8a807b
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Ultraviolet radiation drives mutations in a subset of mucosal melanomas

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