Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models

Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models

Summary: Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) with resistance to neutralizing antibodies are threatening to undermine vaccine efficacy. Vaccination and infection have led to widespread humoral immunity against the pandemic founder (Wu-Hu-1). Against...

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Bibliographic Details
Main Authors: Daniel J. Sheward, Marco Mandolesi, Egon Urgard, Changil Kim, Leo Hanke, Laura Perez Vidakovics, Alec Pankow, Natalie L. Smith, Xaquin Castro Dopico, Gerald M. McInerney, Jonathan M. Coquet, Gunilla B. Karlsson Hedestam, Ben Murrell
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
SARS-CoV-2
variants of concern
vaccines
original antigenic sin
heterotypic boost
passive immunization
Medicine (General)
R5-920
Online Access:https://doaj.org/article/f6fbb94e1aa445b28a40632a0756d791
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