A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction
KLF family transcription factors (KLFs) regulate many cellular processes, including proliferation, survival and stress responses. Here, the authors position KLFs as important regulators of autophagy and lifespan in C. elegans, a role that may extend to the modulation of age-associated vascular pheno...
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Nature Portfolio
2017
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oai:doaj.org-article:f6fefca5fe574b6cb4028da608dba5602021-12-02T14:40:45ZA conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction10.1038/s41467-017-00899-52041-1723https://doaj.org/article/f6fefca5fe574b6cb4028da608dba5602017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00899-5https://doaj.org/toc/2041-1723KLF family transcription factors (KLFs) regulate many cellular processes, including proliferation, survival and stress responses. Here, the authors position KLFs as important regulators of autophagy and lifespan in C. elegans, a role that may extend to the modulation of age-associated vascular phenotypes in mammals.Paishiun N. HsiehGuangjin ZhouYiyuan YuanRongli ZhangDomenick A. ProsdocimoPanjamaporn SangwungAnna H. BortonEvgenii BoriushkinAnne HamikHisashi FujiokaCiaran E. FealyJohn P. KirwanMaureen PetersYuan LuXudong LiaoDiana Ramírez-BergeronZhaoyang FengMukesh K. JainNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Paishiun N. Hsieh Guangjin Zhou Yiyuan Yuan Rongli Zhang Domenick A. Prosdocimo Panjamaporn Sangwung Anna H. Borton Evgenii Boriushkin Anne Hamik Hisashi Fujioka Ciaran E. Fealy John P. Kirwan Maureen Peters Yuan Lu Xudong Liao Diana Ramírez-Bergeron Zhaoyang Feng Mukesh K. Jain A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| description |
KLF family transcription factors (KLFs) regulate many cellular processes, including proliferation, survival and stress responses. Here, the authors position KLFs as important regulators of autophagy and lifespan in C. elegans, a role that may extend to the modulation of age-associated vascular phenotypes in mammals. |
| format |
article |
| author |
Paishiun N. Hsieh Guangjin Zhou Yiyuan Yuan Rongli Zhang Domenick A. Prosdocimo Panjamaporn Sangwung Anna H. Borton Evgenii Boriushkin Anne Hamik Hisashi Fujioka Ciaran E. Fealy John P. Kirwan Maureen Peters Yuan Lu Xudong Liao Diana Ramírez-Bergeron Zhaoyang Feng Mukesh K. Jain |
| author_facet |
Paishiun N. Hsieh Guangjin Zhou Yiyuan Yuan Rongli Zhang Domenick A. Prosdocimo Panjamaporn Sangwung Anna H. Borton Evgenii Boriushkin Anne Hamik Hisashi Fujioka Ciaran E. Fealy John P. Kirwan Maureen Peters Yuan Lu Xudong Liao Diana Ramírez-Bergeron Zhaoyang Feng Mukesh K. Jain |
| author_sort |
Paishiun N. Hsieh |
| title |
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| title_short |
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| title_full |
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| title_fullStr |
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| title_full_unstemmed |
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| title_sort |
conserved klf-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/f6fefca5fe574b6cb4028da608dba560 |
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