The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord

Abstract Descending connections from brainstem nuclei are known to exert powerful control of spinal nociception and pain behaviours in adult mammals. Here we present evidence that descending serotonergic fibres not only inhibit nociceptive activity, but also facilitate non-noxious tactile activity i...

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Autores principales:	F. Schwaller, A. H. Kanellopoulos, M. Fitzgerald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6ffad880eb04ccbae388f1cbce29b6a
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spelling	oai:doaj.org-article:f6ffad880eb04ccbae388f1cbce29b6a2021-12-02T11:52:42ZThe developmental emergence of differential brainstem serotonergic control of the sensory spinal cord10.1038/s41598-017-02509-22045-2322https://doaj.org/article/f6ffad880eb04ccbae388f1cbce29b6a2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02509-2https://doaj.org/toc/2045-2322Abstract Descending connections from brainstem nuclei are known to exert powerful control of spinal nociception and pain behaviours in adult mammals. Here we present evidence that descending serotonergic fibres not only inhibit nociceptive activity, but also facilitate non-noxious tactile activity in the healthy adult rat spinal dorsal horn via activation of spinal 5-HT3 receptors (5-HT3Rs). We further show that this differential serotonergic control in the adult emerges from a non-modality selective system in young rats. Serotonergic fibres exert background 5-HT3R mediated facilitation of both tactile and nociceptive spinal activity in the first three postnatal weeks. Thus, differential descending serotonergic control of spinal touch and pain processing emerges in late postnatal life to allow flexible and context-dependent brain control of somatosensation.F. SchwallerA. H. KanellopoulosM. FitzgeraldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q F. Schwaller A. H. Kanellopoulos M. Fitzgerald The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord
description	Abstract Descending connections from brainstem nuclei are known to exert powerful control of spinal nociception and pain behaviours in adult mammals. Here we present evidence that descending serotonergic fibres not only inhibit nociceptive activity, but also facilitate non-noxious tactile activity in the healthy adult rat spinal dorsal horn via activation of spinal 5-HT3 receptors (5-HT3Rs). We further show that this differential serotonergic control in the adult emerges from a non-modality selective system in young rats. Serotonergic fibres exert background 5-HT3R mediated facilitation of both tactile and nociceptive spinal activity in the first three postnatal weeks. Thus, differential descending serotonergic control of spinal touch and pain processing emerges in late postnatal life to allow flexible and context-dependent brain control of somatosensation.
format	article
author	F. Schwaller A. H. Kanellopoulos M. Fitzgerald
author_facet	F. Schwaller A. H. Kanellopoulos M. Fitzgerald
author_sort	F. Schwaller
title	The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord
title_short	The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord
title_full	The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord
title_fullStr	The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord
title_full_unstemmed	The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord
title_sort	developmental emergence of differential brainstem serotonergic control of the sensory spinal cord
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f6ffad880eb04ccbae388f1cbce29b6a
work_keys_str_mv	AT fschwaller thedevelopmentalemergenceofdifferentialbrainstemserotonergiccontrolofthesensoryspinalcord AT ahkanellopoulos thedevelopmentalemergenceofdifferentialbrainstemserotonergiccontrolofthesensoryspinalcord AT mfitzgerald thedevelopmentalemergenceofdifferentialbrainstemserotonergiccontrolofthesensoryspinalcord AT fschwaller developmentalemergenceofdifferentialbrainstemserotonergiccontrolofthesensoryspinalcord AT ahkanellopoulos developmentalemergenceofdifferentialbrainstemserotonergiccontrolofthesensoryspinalcord AT mfitzgerald developmentalemergenceofdifferentialbrainstemserotonergiccontrolofthesensoryspinalcord
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The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord

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