Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1

The Argonaute protein CSR-1 is essential for fertility and viability in C. elegans. Here the authors show that CSR-1A isoform associates preferentially with small RNAs mapping to spermatogenesis-specific genes while CSR-1B isoform binds small RNAs mapping to oogenesis-specific genes. Arginine methyl...

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Autores principales:	Dieu An H. Nguyen, Carolyn M. Phillips
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7010ea804944715a664118fd09bb117
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spelling	oai:doaj.org-article:f7010ea804944715a664118fd09bb1172021-12-02T15:23:10ZArginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-110.1038/s41467-021-24526-62041-1723https://doaj.org/article/f7010ea804944715a664118fd09bb1172021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24526-6https://doaj.org/toc/2041-1723The Argonaute protein CSR-1 is essential for fertility and viability in C. elegans. Here the authors show that CSR-1A isoform associates preferentially with small RNAs mapping to spermatogenesis-specific genes while CSR-1B isoform binds small RNAs mapping to oogenesis-specific genes. Arginine methylation of CSR-1A promotes small RNA-binding specificity.Dieu An H. NguyenCarolyn M. PhillipsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dieu An H. Nguyen Carolyn M. Phillips Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1
description	The Argonaute protein CSR-1 is essential for fertility and viability in C. elegans. Here the authors show that CSR-1A isoform associates preferentially with small RNAs mapping to spermatogenesis-specific genes while CSR-1B isoform binds small RNAs mapping to oogenesis-specific genes. Arginine methylation of CSR-1A promotes small RNA-binding specificity.
format	article
author	Dieu An H. Nguyen Carolyn M. Phillips
author_facet	Dieu An H. Nguyen Carolyn M. Phillips
author_sort	Dieu An H. Nguyen
title	Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1
title_short	Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1
title_full	Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1
title_fullStr	Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1
title_full_unstemmed	Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1
title_sort	arginine methylation promotes sirna-binding specificity for a spermatogenesis-specific isoform of the argonaute protein csr-1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7010ea804944715a664118fd09bb117
work_keys_str_mv	AT dieuanhnguyen argininemethylationpromotessirnabindingspecificityforaspermatogenesisspecificisoformoftheargonauteproteincsr1 AT carolynmphillips argininemethylationpromotessirnabindingspecificityforaspermatogenesisspecificisoformoftheargonauteproteincsr1
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Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1

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