Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

Toft-Bertelsen et al. describe repurposing of anti-influenza drug amantadine and its derivatives for the treatment of SARS-CoV-2. They show that Amantadine, Emodin and Xanthene show significant blockage of ionchannels formed by SARS-CoV-2 which are crucial for its assembly and pathophysiology.

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Detalles Bibliográficos
Autores principales:	Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B. Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f7013bc495364bc4bcb0878e0dba41ad
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spelling	oai:doaj.org-article:f7013bc495364bc4bcb0878e0dba41ad2021-12-05T12:08:06ZAmantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-210.1038/s42003-021-02866-92399-3642https://doaj.org/article/f7013bc495364bc4bcb0878e0dba41ad2021-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02866-9https://doaj.org/toc/2399-3642Toft-Bertelsen et al. describe repurposing of anti-influenza drug amantadine and its derivatives for the treatment of SARS-CoV-2. They show that Amantadine, Emodin and Xanthene show significant blockage of ionchannels formed by SARS-CoV-2 which are crucial for its assembly and pathophysiology.Trine Lisberg Toft-BertelsenMads Gravers JeppesenEva TzortziniKai XueKarin GillerStefan BeckerAmer MujezinovicBo Hjorth BentzenLoren B. AndreasAntonios KolocourisThomas Nitschke KledalMette Marie RosenkildeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Trine Lisberg Toft-Bertelsen Mads Gravers Jeppesen Eva Tzortzini Kai Xue Karin Giller Stefan Becker Amer Mujezinovic Bo Hjorth Bentzen Loren B. Andreas Antonios Kolocouris Thomas Nitschke Kledal Mette Marie Rosenkilde Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2
description	Toft-Bertelsen et al. describe repurposing of anti-influenza drug amantadine and its derivatives for the treatment of SARS-CoV-2. They show that Amantadine, Emodin and Xanthene show significant blockage of ionchannels formed by SARS-CoV-2 which are crucial for its assembly and pathophysiology.
format	article
author	Trine Lisberg Toft-Bertelsen Mads Gravers Jeppesen Eva Tzortzini Kai Xue Karin Giller Stefan Becker Amer Mujezinovic Bo Hjorth Bentzen Loren B. Andreas Antonios Kolocouris Thomas Nitschke Kledal Mette Marie Rosenkilde
author_facet	Trine Lisberg Toft-Bertelsen Mads Gravers Jeppesen Eva Tzortzini Kai Xue Karin Giller Stefan Becker Amer Mujezinovic Bo Hjorth Bentzen Loren B. Andreas Antonios Kolocouris Thomas Nitschke Kledal Mette Marie Rosenkilde
author_sort	Trine Lisberg Toft-Bertelsen
title	Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2
title_short	Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2
title_full	Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2
title_fullStr	Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2
title_full_unstemmed	Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2
title_sort	amantadine has potential for the treatment of covid-19 because it inhibits known and novel ion channels encoded by sars-cov-2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7013bc495364bc4bcb0878e0dba41ad
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Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

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