Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling

Stimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting metabotropic glutamate signaling, the non-stimulant mGluR activator fasoracetam is well tolerated and may be beneficial in alleviating...

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Autores principales:	Josephine Elia, Grace Ungal, Charlly Kao, Alexander Ambrosini, Nilsa De Jesus-Rosario, Lene Larsen, Rosetta Chiavacci, Tiancheng Wang, Christine Kurian, Kanani Titchen, Brian Sykes, Sharon Hwang, Bhumi Kumar, Jacqueline Potts, Joshua Davis, Jeffrey Malatack, Emma Slattery, Ganesh Moorthy, Athena Zuppa, Andrew Weller, Enda Byrne, Yun R. Li, Walter K. Kraft, Hakon Hakonarson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f704f752c78842ffbb277c912a01949b
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spelling	oai:doaj.org-article:f704f752c78842ffbb277c912a01949b2021-12-02T17:31:58ZFasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling10.1038/s41467-017-02244-22041-1723https://doaj.org/article/f704f752c78842ffbb277c912a01949b2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02244-2https://doaj.org/toc/2041-1723Stimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting metabotropic glutamate signaling, the non-stimulant mGluR activator fasoracetam is well tolerated and may be beneficial in alleviating symptoms of this disease.Josephine EliaGrace UngalCharlly KaoAlexander AmbrosiniNilsa De Jesus-RosarioLene LarsenRosetta ChiavacciTiancheng WangChristine KurianKanani TitchenBrian SykesSharon HwangBhumi KumarJacqueline PottsJoshua DavisJeffrey MalatackEmma SlatteryGanesh MoorthyAthena ZuppaAndrew WellerEnda ByrneYun R. LiWalter K. KraftHakon HakonarsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Josephine Elia Grace Ungal Charlly Kao Alexander Ambrosini Nilsa De Jesus-Rosario Lene Larsen Rosetta Chiavacci Tiancheng Wang Christine Kurian Kanani Titchen Brian Sykes Sharon Hwang Bhumi Kumar Jacqueline Potts Joshua Davis Jeffrey Malatack Emma Slattery Ganesh Moorthy Athena Zuppa Andrew Weller Enda Byrne Yun R. Li Walter K. Kraft Hakon Hakonarson Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling
description	Stimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting metabotropic glutamate signaling, the non-stimulant mGluR activator fasoracetam is well tolerated and may be beneficial in alleviating symptoms of this disease.
format	article
author	Josephine Elia Grace Ungal Charlly Kao Alexander Ambrosini Nilsa De Jesus-Rosario Lene Larsen Rosetta Chiavacci Tiancheng Wang Christine Kurian Kanani Titchen Brian Sykes Sharon Hwang Bhumi Kumar Jacqueline Potts Joshua Davis Jeffrey Malatack Emma Slattery Ganesh Moorthy Athena Zuppa Andrew Weller Enda Byrne Yun R. Li Walter K. Kraft Hakon Hakonarson
author_facet	Josephine Elia Grace Ungal Charlly Kao Alexander Ambrosini Nilsa De Jesus-Rosario Lene Larsen Rosetta Chiavacci Tiancheng Wang Christine Kurian Kanani Titchen Brian Sykes Sharon Hwang Bhumi Kumar Jacqueline Potts Joshua Davis Jeffrey Malatack Emma Slattery Ganesh Moorthy Athena Zuppa Andrew Weller Enda Byrne Yun R. Li Walter K. Kraft Hakon Hakonarson
author_sort	Josephine Elia
title	Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling
title_short	Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling
title_full	Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling
title_fullStr	Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling
title_full_unstemmed	Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling
title_sort	fasoracetam in adolescents with adhd and glutamatergic gene network variants disrupting mglur neurotransmitter signaling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f704f752c78842ffbb277c912a01949b
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Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling

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