Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion

Emine Dogan,1 Ozkan Sever,2 Burcin Köklü Çakir,1 Erkan Celik1 1Department of Ophthalmology, Sakarya University Medical Education and Research Hospital, Sakarya, Turkey; 2Department of Ophthalmology, Namik Kemal University School of Medicine, Namik Kemal University, Teki...

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Autores principales:	Dogan E, Sever O, Köklü Çakir B, Celik E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Ranibizumab Vein occlusion Serous detachment Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f7078d45573945d2b78bfc515c250b47
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spelling	oai:doaj.org-article:f7078d45573945d2b78bfc515c250b472021-12-02T06:19:48ZEffect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion1177-5483https://doaj.org/article/f7078d45573945d2b78bfc515c250b472018-08-01T00:00:00Zhttps://www.dovepress.com/effect-of-intravitreal-ranibizumab-on-serous-retinal-detachment-in-bra-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Emine Dogan,1 Ozkan Sever,2 Burcin Köklü Çakir,1 Erkan Celik1 1Department of Ophthalmology, Sakarya University Medical Education and Research Hospital, Sakarya, Turkey; 2Department of Ophthalmology, Namik Kemal University School of Medicine, Namik Kemal University, Tekirdag, Turkey Purpose: The aim of this study was to evaluate the effect of initial intravitreal ranibizumab injection on visual acuity (VA) and central macular thickness (CMT) for the treatment of macular edema (ME) with and without serous retinal detachment (SRD) secondary to branch retinal vein occlusion (BRVO). Materials and methods: Fifty-two BRVO eyes, treated with intravitreal ranibizumab injection for ME with and without SRD, were retrospectively reviewed. Patients were divided into two groups according to spectral domain optical coherence tomography (SD-OCT). The efficacy of intravitreal ranibizumab injection at first month was assessed by analyzing the change in best-corrected VA and reduction in CMT with SD-OCT. Results: There were 21 patients with SRD and 31 patients with only CME (no-SRD). CMT was significantly greater in the SRD group than in the CME group (451±62.2 µm vs 383.5±37.2 µm, respectively, P<0.05). After initial intravitreal ranibizumab injection, mean VA improved from 0.87±0.26 logarithm of the minimum angle of resolution (LogMAR) to 0.54±0.27 LogMAR (P<0.01) and CMT decreased from 451±62.2 µm to 379.3±58.6 µm (P<0.001) in the SRD group. In the no-SRD group, mean VA improved from 0.69±0.25 LogMAR to 0.44±0.25 LogMAR (P<0.001) and the CMT decreased from 383.5±37.2 µm to 337.7±39.4 µm (P<0.001) at the first month visit. Eyes with SRD revealed better anatomic results and greater reduction of CMT after intravitreal ranibizumab injection (P<0.01). Conclusion: VA and CMT can be improved by intravitreal ranibizumab injection in BRVO patients with and without SRD. However, more marked improvement in macular morphology was achieved in patients with SRD than those without SRD. Keywords: ranibizumab, vein occlusion, serous detachmentDogan ESever OKöklü Çakir BCelik EDove Medical PressarticleRanibizumabVein occlusionSerous detachmentOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1465-1470 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ranibizumab Vein occlusion Serous detachment Ophthalmology RE1-994
spellingShingle	Ranibizumab Vein occlusion Serous detachment Ophthalmology RE1-994 Dogan E Sever O Köklü Çakir B Celik E Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
description	Emine Dogan,1 Ozkan Sever,2 Burcin Köklü Çakir,1 Erkan Celik1 1Department of Ophthalmology, Sakarya University Medical Education and Research Hospital, Sakarya, Turkey; 2Department of Ophthalmology, Namik Kemal University School of Medicine, Namik Kemal University, Tekirdag, Turkey Purpose: The aim of this study was to evaluate the effect of initial intravitreal ranibizumab injection on visual acuity (VA) and central macular thickness (CMT) for the treatment of macular edema (ME) with and without serous retinal detachment (SRD) secondary to branch retinal vein occlusion (BRVO). Materials and methods: Fifty-two BRVO eyes, treated with intravitreal ranibizumab injection for ME with and without SRD, were retrospectively reviewed. Patients were divided into two groups according to spectral domain optical coherence tomography (SD-OCT). The efficacy of intravitreal ranibizumab injection at first month was assessed by analyzing the change in best-corrected VA and reduction in CMT with SD-OCT. Results: There were 21 patients with SRD and 31 patients with only CME (no-SRD). CMT was significantly greater in the SRD group than in the CME group (451±62.2 µm vs 383.5±37.2 µm, respectively, P<0.05). After initial intravitreal ranibizumab injection, mean VA improved from 0.87±0.26 logarithm of the minimum angle of resolution (LogMAR) to 0.54±0.27 LogMAR (P<0.01) and CMT decreased from 451±62.2 µm to 379.3±58.6 µm (P<0.001) in the SRD group. In the no-SRD group, mean VA improved from 0.69±0.25 LogMAR to 0.44±0.25 LogMAR (P<0.001) and the CMT decreased from 383.5±37.2 µm to 337.7±39.4 µm (P<0.001) at the first month visit. Eyes with SRD revealed better anatomic results and greater reduction of CMT after intravitreal ranibizumab injection (P<0.01). Conclusion: VA and CMT can be improved by intravitreal ranibizumab injection in BRVO patients with and without SRD. However, more marked improvement in macular morphology was achieved in patients with SRD than those without SRD. Keywords: ranibizumab, vein occlusion, serous detachment
format	article
author	Dogan E Sever O Köklü Çakir B Celik E
author_facet	Dogan E Sever O Köklü Çakir B Celik E
author_sort	Dogan E
title	Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title_short	Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title_full	Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title_fullStr	Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title_full_unstemmed	Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
title_sort	effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f7078d45573945d2b78bfc515c250b47
work_keys_str_mv	AT dogane effectofintravitrealranibizumabonserousretinaldetachmentinbranchretinalveinocclusion AT severo effectofintravitrealranibizumabonserousretinaldetachmentinbranchretinalveinocclusion AT koklucakirb effectofintravitrealranibizumabonserousretinaldetachmentinbranchretinalveinocclusion AT celike effectofintravitrealranibizumabonserousretinaldetachmentinbranchretinalveinocclusion
_version_	1718399969708212224

Effect of intravitreal ranibizumab on serous retinal detachment in branch retinal vein occlusion

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