DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).

Twin-studies suggest that a significant portion of individual differences in the propensity to take risks resides in people's genetic make-up and there is evidence that variability in dopaminergic systems relates to individual differences in risky choice. We examined the link between risk takin...

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Autores principales:	Rui Mata, Robin Hau, Andreas Papassotiropoulos, Ralph Hertwig
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f707f8635e144de6bcc01610b544f335
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spelling	oai:doaj.org-article:f707f8635e144de6bcc01610b544f3352021-11-18T07:15:09ZDAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).1932-620310.1371/journal.pone.0039135https://doaj.org/article/f707f8635e144de6bcc01610b544f3352012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22723947/?tool=EBIhttps://doaj.org/toc/1932-6203Twin-studies suggest that a significant portion of individual differences in the propensity to take risks resides in people's genetic make-up and there is evidence that variability in dopaminergic systems relates to individual differences in risky choice. We examined the link between risk taking in a risk taking task (the Balloon Analogue Risk Task, BART) and a variable number tandem repeat (VNTR) polymorphism in the 3'UTR of the dopamine transporter gene (SLC6A3/DAT1). Behavior in BART is known to be associated with activity in striatal reward-processing regions, and DAT1 is assumed to modulate striatal dopamine levels. We find that carriers of DAT1 alleles, which presumably result in lower striatal dopamine availability, showed more risk taking, relative to carriers of the alleles associated with higher striatal dopamine availability. Our analyses suggest that the mechanism underlying this association is diminished sensitivity to rewards among those who take more risks. Overall, our results support the notion that a behavioral genetic approach can be helpful in uncovering the basis of individual differences in risk taking.Rui MataRobin HauAndreas PapassotiropoulosRalph HertwigPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39135 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rui Mata Robin Hau Andreas Papassotiropoulos Ralph Hertwig DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).
description	Twin-studies suggest that a significant portion of individual differences in the propensity to take risks resides in people's genetic make-up and there is evidence that variability in dopaminergic systems relates to individual differences in risky choice. We examined the link between risk taking in a risk taking task (the Balloon Analogue Risk Task, BART) and a variable number tandem repeat (VNTR) polymorphism in the 3'UTR of the dopamine transporter gene (SLC6A3/DAT1). Behavior in BART is known to be associated with activity in striatal reward-processing regions, and DAT1 is assumed to modulate striatal dopamine levels. We find that carriers of DAT1 alleles, which presumably result in lower striatal dopamine availability, showed more risk taking, relative to carriers of the alleles associated with higher striatal dopamine availability. Our analyses suggest that the mechanism underlying this association is diminished sensitivity to rewards among those who take more risks. Overall, our results support the notion that a behavioral genetic approach can be helpful in uncovering the basis of individual differences in risk taking.
format	article
author	Rui Mata Robin Hau Andreas Papassotiropoulos Ralph Hertwig
author_facet	Rui Mata Robin Hau Andreas Papassotiropoulos Ralph Hertwig
author_sort	Rui Mata
title	DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).
title_short	DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).
title_full	DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).
title_fullStr	DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).
title_full_unstemmed	DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).
title_sort	dat1 polymorphism is associated with risk taking in the balloon analogue risk task (bart).
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/f707f8635e144de6bcc01610b544f335
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DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).

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