Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm

Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm

Perturbations of the cardiopharyngeal mesoderm can lead to congenital defects in individuals with 22q11.2 deletion syndrome. Here the authors use single cell RNA-sequencing to identify a multilineage primed population within the mesoderm, marked by Tbx1, which has bipotent properties to form cardiac...

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Autores principales: Hiroko Nomaru, Yang Liu, Christopher De Bono, Dario Righelli, Andrea Cirino, Wei Wang, Hansoo Song, Silvia E. Racedo, Anelisa G. Dantas, Lu Zhang, Chen-Leng Cai, Claudia Angelini, Lionel Christiaen, Robert G. Kelly, Antonio Baldini, Deyou Zheng, Bernice E. Morrow
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/f709a55fc0cc4c0b854e870ae4c8e741
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Sumario:Perturbations of the cardiopharyngeal mesoderm can lead to congenital defects in individuals with 22q11.2 deletion syndrome. Here the authors use single cell RNA-sequencing to identify a multilineage primed population within the mesoderm, marked by Tbx1, which has bipotent properties to form cardiac and branchiomeric muscle cells.

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