Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm

Perturbations of the cardiopharyngeal mesoderm can lead to congenital defects in individuals with 22q11.2 deletion syndrome. Here the authors use single cell RNA-sequencing to identify a multilineage primed population within the mesoderm, marked by Tbx1, which has bipotent properties to form cardiac...

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Autores principales:	Hiroko Nomaru, Yang Liu, Christopher De Bono, Dario Righelli, Andrea Cirino, Wei Wang, Hansoo Song, Silvia E. Racedo, Anelisa G. Dantas, Lu Zhang, Chen-Leng Cai, Claudia Angelini, Lionel Christiaen, Robert G. Kelly, Antonio Baldini, Deyou Zheng, Bernice E. Morrow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f709a55fc0cc4c0b854e870ae4c8e741
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spelling	oai:doaj.org-article:f709a55fc0cc4c0b854e870ae4c8e7412021-11-21T12:34:26ZSingle cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm10.1038/s41467-021-26966-62041-1723https://doaj.org/article/f709a55fc0cc4c0b854e870ae4c8e7412021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26966-6https://doaj.org/toc/2041-1723Perturbations of the cardiopharyngeal mesoderm can lead to congenital defects in individuals with 22q11.2 deletion syndrome. Here the authors use single cell RNA-sequencing to identify a multilineage primed population within the mesoderm, marked by Tbx1, which has bipotent properties to form cardiac and branchiomeric muscle cells.Hiroko NomaruYang LiuChristopher De BonoDario RighelliAndrea CirinoWei WangHansoo SongSilvia E. RacedoAnelisa G. DantasLu ZhangChen-Leng CaiClaudia AngeliniLionel ChristiaenRobert G. KellyAntonio BaldiniDeyou ZhengBernice E. MorrowNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroko Nomaru Yang Liu Christopher De Bono Dario Righelli Andrea Cirino Wei Wang Hansoo Song Silvia E. Racedo Anelisa G. Dantas Lu Zhang Chen-Leng Cai Claudia Angelini Lionel Christiaen Robert G. Kelly Antonio Baldini Deyou Zheng Bernice E. Morrow Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm
description	Perturbations of the cardiopharyngeal mesoderm can lead to congenital defects in individuals with 22q11.2 deletion syndrome. Here the authors use single cell RNA-sequencing to identify a multilineage primed population within the mesoderm, marked by Tbx1, which has bipotent properties to form cardiac and branchiomeric muscle cells.
format	article
author	Hiroko Nomaru Yang Liu Christopher De Bono Dario Righelli Andrea Cirino Wei Wang Hansoo Song Silvia E. Racedo Anelisa G. Dantas Lu Zhang Chen-Leng Cai Claudia Angelini Lionel Christiaen Robert G. Kelly Antonio Baldini Deyou Zheng Bernice E. Morrow
author_facet	Hiroko Nomaru Yang Liu Christopher De Bono Dario Righelli Andrea Cirino Wei Wang Hansoo Song Silvia E. Racedo Anelisa G. Dantas Lu Zhang Chen-Leng Cai Claudia Angelini Lionel Christiaen Robert G. Kelly Antonio Baldini Deyou Zheng Bernice E. Morrow
author_sort	Hiroko Nomaru
title	Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm
title_short	Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm
title_full	Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm
title_fullStr	Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm
title_full_unstemmed	Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm
title_sort	single cell multi-omic analysis identifies a tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f709a55fc0cc4c0b854e870ae4c8e741
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Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm

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